卵巢储备标志物在育龄妇女癫痫

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES

Epilepsy & Behavior Pub Date : 2025-09-05 DOI:10.1016/j.yebeh.2025.110661

Clara Colombo , Janne G. Bentzen , Michael Oettinger , Henriette Ewers , Lars H. Pinborg , Anja Pinborg , Anne Sabers

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引用次数: 0

摘要

目的本研究的目的是比较癫痫女性与非癫痫女性的卵巢储备参数。方法在2018-2022年间，共有80名来自丹麦Rigshospitalet癫痫诊所的癫痫女性（WWE）参与并完成了研究。2008年至2010年收集的418名无癫痫且未诊断为不孕症的妇女作为对照。在卵泡早期（周期2-5天）评估卵巢储备标志物，包括血清抗勒氏杆菌激素（AMH）和经阴道超声检测的窦卵泡计数（AFC）。比较WWE组和对照组以及WWE组亚组间年龄调整卵巢储备参数。结果各组间AMH差异无统计学意义，平均AMH分别为21.9 (15.0)pmol/L和21.7 (18.0)pmol/L （p = 0.93）。WWE组的AFC平均值为28.3（16.4）高于对照组的22.7 (12.0)（p = 0.01）。校正年龄后，AFC的差异仍然显著（p = 0.035）。在比较WWE亚组时，没有发现基于主要癫痫发作类型的差异。结论：总体而言，癫痫女性的卵巢储备能力没有下降，卵巢储备能力的年龄调整指标（AMH和AFC水平）与对照组无癫痫女性相当。在日常临床实践中，这为育龄癫痫妇女提供了令人放心的重要信息，她们经常担心自己的生殖健康。

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Ovarian reserve markers in women of reproductive ages with epilepsy

Objective

The objective of this study was to examine ovarian reserve parameters in women with epilepsy compared to women without epilepsy.

Methods

A total of 80 women with epilepsy (WWE) from the epilepsy clinic at Rigshospitalet, Denmark, participated and completed the study between 2018–2022. A historical cohort collected from 2008 to 2010 of 418 women without epilepsy and no prior diagnosis of infertility was used as control.

Ovarian reserve markers, including serum anti-Müllerian hormone (AMH) and antral follicle count (AFC) measured via transvaginal ultrasound, were assessed during the early follicular phase (cycle days 2–5). Age-adjusted ovarian reserve parameters were compared between WWE and controls, as well as among subgroups of WWE.

Results

There was no difference in AMH between the groups with mean AMH of 21.9 (15.0) pmol/L and 21.7 (18.0) pmol/L, respectively (p = 0.93). AFC was higher in WWE with a mean of 28.3 (16.4) compared to 22.7 (12.0) in the control group (p = 0.01). The difference in AFC remained significant after adjusting for age (p = 0.035). No differences were found when comparing subgroups of WWE based on the dominating seizure type.

Conclusion

Overall, women with epilepsy did not have diminished ovarian reserve as age-adjusted markers of ovarian reserve (AMH and AFC levels) were comparable to a control group of women without epilepsy. In daily clinical practice, this provides reassuring and important information to communicate to women with epilepsy of reproductive age, who are often concerned about their reproductive health.

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.