Katerina M Antoniou,Oliver Distler,Ana-Maria Gheorghiu,Catharina C Moor,Jens Vikse,Nikoleta Bizymi,Ilaria Galetti,Graham Brown,Elena Bargagli,Yannick Allanore,Tamera J Corte,Philippe Dieudé,Vincent Cottin,Benjamin A Fisher,Aurelie Fabre,Jon T Giles,Michael Kreuter,Ingrid E Lundberg,Venerino Poletti,Britta Maurer,Elisabetta A Renzoni,Ulf Müller-Ladner,Mary E Strek,Nicola Sverzellati,Paul Studenic,Jibril Mohammed,Blin Nagavci,Tanja Stamm,Thomy Tonia,Bruno Crestani,Anna-Maria Hoffmann-Vold
{"title":"结缔组织病相关间质性肺病的ERS/EULAR临床实践指南由欧洲呼吸学会(ERS)和欧洲风湿病协会联盟(EULAR)的结缔组织病相关间质性肺病工作组制定,并得到欧洲罕见呼吸疾病参考网络(ERN-LUNG)的认可。","authors":"Katerina M Antoniou,Oliver Distler,Ana-Maria Gheorghiu,Catharina C Moor,Jens Vikse,Nikoleta Bizymi,Ilaria Galetti,Graham Brown,Elena Bargagli,Yannick Allanore,Tamera J Corte,Philippe Dieudé,Vincent Cottin,Benjamin A Fisher,Aurelie Fabre,Jon T Giles,Michael Kreuter,Ingrid E Lundberg,Venerino Poletti,Britta Maurer,Elisabetta A Renzoni,Ulf Müller-Ladner,Mary E Strek,Nicola Sverzellati,Paul Studenic,Jibril Mohammed,Blin Nagavci,Tanja Stamm,Thomy Tonia,Bruno Crestani,Anna-Maria Hoffmann-Vold","doi":"10.1183/13993003.02533-2024","DOIUrl":null,"url":null,"abstract":"BACKGROUND\r\nInterstitial lung disease (ILD) is a frequent manifestation of connective tissue diseases (CTDs) and is associated with high morbidity and mortality. Clinical practice guidelines to standardise screening, diagnosis, treatment and follow-up for CTD-ILD are of high importance for optimised patient care.\r\n\r\nMETHODS\r\nA European Respiratory Society and European Alliance of Associations for Rheumatology task force committee, composed of pulmonologists, rheumatologists, pathologists, radiologists, methodologists and patient representatives, developed recommendations based on PICO (Patients, Intervention, Comparison, Outcomes) questions with grading of the evidence according to the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) methodology and complementary narrative questions agreed on by both societies. For both PICO and narrative questions, the Evidence to Decision framework was used to formulate the recommendations.\r\n\r\nRESULTS\r\nThe task force committee concluded with recommendations for 25 PICO and 28 narrative questions, regarding ILD in the context of systemic sclerosis, rheumatoid arthritis (RA), idiopathic inflammatory myopathies, Sjögren disease (SjD), systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). In four narrative questions, regarding screening and assessment of risk for ILD progression in MCTD, SjD and SLE and one PICO question regarding pirfenidone in CTD-ILD other than RA-ILD, the task force had insufficient evidence to support recommendations. Screening, diagnostic, monitoring and treatment algorithms were developed based on the recommendations and usual clinical practice.\r\n\r\nCONCLUSIONS\r\nWe provide practical guidance by evidence-based recommendations to clinicians for each of the CTDs. In many cases there is low certainty or absence of evidence and we encourage further research to fill these gaps.","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"14 1","pages":""},"PeriodicalIF":21.0000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ERS/EULAR clinical practice guidelines for connective tissue disease-associated interstitial lung diseaseDeveloped by the task force for connective tissue disease-associated interstitial lung disease of the European Respiratory Society (ERS) and the European Alliance of Associations for Rheumatology (EULAR)Endorsed by the European Reference Network on rare respiratory diseases (ERN-LUNG).\",\"authors\":\"Katerina M Antoniou,Oliver Distler,Ana-Maria Gheorghiu,Catharina C Moor,Jens Vikse,Nikoleta Bizymi,Ilaria Galetti,Graham Brown,Elena Bargagli,Yannick Allanore,Tamera J Corte,Philippe Dieudé,Vincent Cottin,Benjamin A Fisher,Aurelie Fabre,Jon T Giles,Michael Kreuter,Ingrid E Lundberg,Venerino Poletti,Britta Maurer,Elisabetta A Renzoni,Ulf Müller-Ladner,Mary E Strek,Nicola Sverzellati,Paul Studenic,Jibril Mohammed,Blin Nagavci,Tanja Stamm,Thomy Tonia,Bruno Crestani,Anna-Maria Hoffmann-Vold\",\"doi\":\"10.1183/13993003.02533-2024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"BACKGROUND\\r\\nInterstitial lung disease (ILD) is a frequent manifestation of connective tissue diseases (CTDs) and is associated with high morbidity and mortality. Clinical practice guidelines to standardise screening, diagnosis, treatment and follow-up for CTD-ILD are of high importance for optimised patient care.\\r\\n\\r\\nMETHODS\\r\\nA European Respiratory Society and European Alliance of Associations for Rheumatology task force committee, composed of pulmonologists, rheumatologists, pathologists, radiologists, methodologists and patient representatives, developed recommendations based on PICO (Patients, Intervention, Comparison, Outcomes) questions with grading of the evidence according to the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) methodology and complementary narrative questions agreed on by both societies. For both PICO and narrative questions, the Evidence to Decision framework was used to formulate the recommendations.\\r\\n\\r\\nRESULTS\\r\\nThe task force committee concluded with recommendations for 25 PICO and 28 narrative questions, regarding ILD in the context of systemic sclerosis, rheumatoid arthritis (RA), idiopathic inflammatory myopathies, Sjögren disease (SjD), systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). In four narrative questions, regarding screening and assessment of risk for ILD progression in MCTD, SjD and SLE and one PICO question regarding pirfenidone in CTD-ILD other than RA-ILD, the task force had insufficient evidence to support recommendations. Screening, diagnostic, monitoring and treatment algorithms were developed based on the recommendations and usual clinical practice.\\r\\n\\r\\nCONCLUSIONS\\r\\nWe provide practical guidance by evidence-based recommendations to clinicians for each of the CTDs. In many cases there is low certainty or absence of evidence and we encourage further research to fill these gaps.\",\"PeriodicalId\":12265,\"journal\":{\"name\":\"European Respiratory Journal\",\"volume\":\"14 1\",\"pages\":\"\"},\"PeriodicalIF\":21.0000,\"publicationDate\":\"2025-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Respiratory Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1183/13993003.02533-2024\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Respiratory Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1183/13993003.02533-2024","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
ERS/EULAR clinical practice guidelines for connective tissue disease-associated interstitial lung diseaseDeveloped by the task force for connective tissue disease-associated interstitial lung disease of the European Respiratory Society (ERS) and the European Alliance of Associations for Rheumatology (EULAR)Endorsed by the European Reference Network on rare respiratory diseases (ERN-LUNG).
BACKGROUND
Interstitial lung disease (ILD) is a frequent manifestation of connective tissue diseases (CTDs) and is associated with high morbidity and mortality. Clinical practice guidelines to standardise screening, diagnosis, treatment and follow-up for CTD-ILD are of high importance for optimised patient care.
METHODS
A European Respiratory Society and European Alliance of Associations for Rheumatology task force committee, composed of pulmonologists, rheumatologists, pathologists, radiologists, methodologists and patient representatives, developed recommendations based on PICO (Patients, Intervention, Comparison, Outcomes) questions with grading of the evidence according to the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) methodology and complementary narrative questions agreed on by both societies. For both PICO and narrative questions, the Evidence to Decision framework was used to formulate the recommendations.
RESULTS
The task force committee concluded with recommendations for 25 PICO and 28 narrative questions, regarding ILD in the context of systemic sclerosis, rheumatoid arthritis (RA), idiopathic inflammatory myopathies, Sjögren disease (SjD), systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). In four narrative questions, regarding screening and assessment of risk for ILD progression in MCTD, SjD and SLE and one PICO question regarding pirfenidone in CTD-ILD other than RA-ILD, the task force had insufficient evidence to support recommendations. Screening, diagnostic, monitoring and treatment algorithms were developed based on the recommendations and usual clinical practice.
CONCLUSIONS
We provide practical guidance by evidence-based recommendations to clinicians for each of the CTDs. In many cases there is low certainty or absence of evidence and we encourage further research to fill these gaps.
期刊介绍:
The European Respiratory Journal (ERJ) is the flagship journal of the European Respiratory Society. It has a current impact factor of 24.9. The journal covers various aspects of adult and paediatric respiratory medicine, including cell biology, epidemiology, immunology, oncology, pathophysiology, imaging, occupational medicine, intensive care, sleep medicine, and thoracic surgery. In addition to original research material, the ERJ publishes editorial commentaries, reviews, short research letters, and correspondence to the editor. The articles are published continuously and collected into 12 monthly issues in two volumes per year.