{"title":"氧化酶亚基出人意料地阻止钙泵氧化和心功能障碍。","authors":"","doi":"10.1038/s44161-025-00703-4","DOIUrl":null,"url":null,"abstract":"This study identifies a non-canonical role of p22phox (a subunit of NADPH oxidases) in cardiac protection: by directly binding the sarcoplasmic reticulum calcium pump SERCA2a and preventing its oxidation, p22phox preserves SERCA2a stability and maintains calcium cycling and cardiac function under stress. This mechanism is crucial for modulating SERCA2a levels in heart failure.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 9","pages":"1045-1046"},"PeriodicalIF":10.8000,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Oxidase subunit unexpectedly prevents oxidation of calcium pump and cardiac dysfunction\",\"authors\":\"\",\"doi\":\"10.1038/s44161-025-00703-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study identifies a non-canonical role of p22phox (a subunit of NADPH oxidases) in cardiac protection: by directly binding the sarcoplasmic reticulum calcium pump SERCA2a and preventing its oxidation, p22phox preserves SERCA2a stability and maintains calcium cycling and cardiac function under stress. This mechanism is crucial for modulating SERCA2a levels in heart failure.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"4 9\",\"pages\":\"1045-1046\"},\"PeriodicalIF\":10.8000,\"publicationDate\":\"2025-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-025-00703-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-025-00703-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Oxidase subunit unexpectedly prevents oxidation of calcium pump and cardiac dysfunction
This study identifies a non-canonical role of p22phox (a subunit of NADPH oxidases) in cardiac protection: by directly binding the sarcoplasmic reticulum calcium pump SERCA2a and preventing its oxidation, p22phox preserves SERCA2a stability and maintains calcium cycling and cardiac function under stress. This mechanism is crucial for modulating SERCA2a levels in heart failure.
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