{"title":"新一代宏基因组测序在血液病感染病原学诊断中的应用专家共识（2024）。","authors":"Chunhui Xu, Ren Lin, Ye Bai, Yanqiu Han, Jianda Hu, Jiong Hu, Yu Hu, Fen Huang, Xiaojun Huang, Chunyan Ji, Xin Li, Aibin Liang, Peihua Lu, Jun Ma, Heng Mei, Ting Niu, Jian Ouyang, Wenbin Qian, Jimin Shi, Yongping Song, Aining Sun, Yehui Tan, Hui Wang, Jianxiang Wang, Yu Wang, Depei Wu, Zhijian Xiao, Ting Yang, Cheng Zhang, Xi Zhang, Xiaohui Zhang, Weili Zhao, Zhuanzhen Zheng, Zunmin Zhu, Sizhou Feng, Qifa Liu","doi":"10.1097/BS9.0000000000000241","DOIUrl":null,"url":null,"abstract":"<p><p>Infections are frequent complications in patients with hematological disorders, and pathogen diagnosis remains challenging. Metagenomic next-generation sequencing (mNGS) is an unbiased high-throughput technology that has been widely applied in the diagnosis of infectious diseases. However, to date, there are no established international guidelines or expert consensuses regarding the use of mNGS to diagnose infections in patients with hematologic disorders. The Anti-Infection Study Group of the Chinese Society of Hematology invited experts in the fields of hematology, microbiology, and mNGS technology to draft an expert consensus focused on clinical indications, sample collection, quality control, and interpretation of results. This consensus will likely contribute to clarifying the medical indications for mNGS testing, optimizing the interpretation of reports, and becoming an inspiration for global practice.</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"7 3","pages":"e00241"},"PeriodicalIF":2.7000,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401339/pdf/","citationCount":"0","resultStr":"{\"title\":\"China Expert consensus on the application of metagenomic next-generation sequencing for the etiological diagnosis of infections in hematological disorders (2024).\",\"authors\":\"Chunhui Xu, Ren Lin, Ye Bai, Yanqiu Han, Jianda Hu, Jiong Hu, Yu Hu, Fen Huang, Xiaojun Huang, Chunyan Ji, Xin Li, Aibin Liang, Peihua Lu, Jun Ma, Heng Mei, Ting Niu, Jian Ouyang, Wenbin Qian, Jimin Shi, Yongping Song, Aining Sun, Yehui Tan, Hui Wang, Jianxiang Wang, Yu Wang, Depei Wu, Zhijian Xiao, Ting Yang, Cheng Zhang, Xi Zhang, Xiaohui Zhang, Weili Zhao, Zhuanzhen Zheng, Zunmin Zhu, Sizhou Feng, Qifa Liu\",\"doi\":\"10.1097/BS9.0000000000000241\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Infections are frequent complications in patients with hematological disorders, and pathogen diagnosis remains challenging. Metagenomic next-generation sequencing (mNGS) is an unbiased high-throughput technology that has been widely applied in the diagnosis of infectious diseases. However, to date, there are no established international guidelines or expert consensuses regarding the use of mNGS to diagnose infections in patients with hematologic disorders. The Anti-Infection Study Group of the Chinese Society of Hematology invited experts in the fields of hematology, microbiology, and mNGS technology to draft an expert consensus focused on clinical indications, sample collection, quality control, and interpretation of results. This consensus will likely contribute to clarifying the medical indications for mNGS testing, optimizing the interpretation of reports, and becoming an inspiration for global practice.</p>\",\"PeriodicalId\":67343,\"journal\":{\"name\":\"血液科学(英文)\",\"volume\":\"7 3\",\"pages\":\"e00241\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401339/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"血液科学(英文)\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/BS9.0000000000000241\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"血液科学(英文)","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/BS9.0000000000000241","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}
China Expert consensus on the application of metagenomic next-generation sequencing for the etiological diagnosis of infections in hematological disorders (2024).
Infections are frequent complications in patients with hematological disorders, and pathogen diagnosis remains challenging. Metagenomic next-generation sequencing (mNGS) is an unbiased high-throughput technology that has been widely applied in the diagnosis of infectious diseases. However, to date, there are no established international guidelines or expert consensuses regarding the use of mNGS to diagnose infections in patients with hematologic disorders. The Anti-Infection Study Group of the Chinese Society of Hematology invited experts in the fields of hematology, microbiology, and mNGS technology to draft an expert consensus focused on clinical indications, sample collection, quality control, and interpretation of results. This consensus will likely contribute to clarifying the medical indications for mNGS testing, optimizing the interpretation of reports, and becoming an inspiration for global practice.
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