肝脏粘液囊性肿瘤:文献回顾和病例系列。

IF 3.2 Q3 ONCOLOGY
Ottavia Cicerone, Giorgia Basilico, Claudio Tassi, Caterina Antoniacomi, Federica Lucev, Salvatore Corallo, Alessandro Vanoli, Marcello Maestri
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引用次数: 0

摘要

肝脏粘液囊性肿瘤(MCN-L)是一种罕见的囊性病变,其特征是产生黏液的上皮和卵巢样间质。尽管MCN-L在肝脏囊性病变中所占比例不到5%,但由于其与其他囊性病变的重叠特征及其恶性转化的可能性,MCN-L在诊断上存在重大挑战。因此,早期识别和明确的手术干预对于确保最佳患者预后至关重要。我们对MCN-L的流行病学、临床表现、诊断方式和治疗策略进行了文献综述。此外,从2019年到2025年,我们中心发现了9例MCN-L患者。回顾性分析临床资料和结果。MCN-L主要影响中年妇女,表现为大的、多室的囊性病变,无胆道通讯。2010年修订的世界卫生组织分类强调卵巢样基质的存在作为明确诊断。对比增强的计算机断层扫描或磁共振成像通常是暗示性的,但不是病态的,加强了对组织病理证实的需要。由于MCN-L与其他囊性肝病变相似,它仍然是诊断和治疗的挑战。完全手术切除是预防复发和恶性转化的治疗选择,加强了早期干预的重要性。需要进一步的研究来提高诊断的准确性和完善的管理策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mucinous cystic neoplasms of the liver: Literature review and case series.

Mucinous cystic neoplasms of the liver (MCN-L) are rare cystic lesions characterized by mucin-producing epithelium and ovarian-like stroma. Although they constitute fewer than 5% of hepatic cystic lesions, MCN-L poses significant diagnostic challenges due to overlapping features with other cystic lesions and their potential for malignant transformation. Early recognition and definitive surgical intervention are therefore critical to ensure optimal patient outcomes. A literature review was conducted to summarize epidemiology, clinical presentation, diagnostic modalities, and management strategies for MCN-L. Additionally, from 2019 to 2025, 9 patients with MCN-L were identified at our center. Clinical data and outcomes were retrospectively analyzed. MCN-L predominantly affects middle-aged women and presents as large, multiloculated cystic lesions without biliary communication. The revised 2010 World Health Organization classification emphasizes the presence of ovarian-like stroma for definitive diagnosis. Contrast-enhanced computed tomography or magnetic resonance imaging are often suggestive but not pathognomonic, reinforcing the need for histopathological confirmation. MCN-L remains a diagnostic and therapeutic challenge due to its resemblance to other cystic liver lesions. Complete surgical resection is the treatment of choice to prevent recurrence and malignant transformation, reinforcing the importance of early intervention. Further research is needed to improve diagnostic accuracy and refine management strategies.

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来源期刊
自引率
0.00%
发文量
585
期刊介绍: The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.
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