肠道微生物组及其对造血干细胞移植后预后的影响:一项综合综述。

IF 4.2 3区 医学 Q2 CELL & TISSUE ENGINEERING
Stem Cell Reviews and Reports Pub Date : 2025-11-01 Epub Date: 2025-09-04 DOI:10.1007/s12015-025-10958-w
Babak Arjmand, Sana Badamchizadeh, Pouya Mehran, Maedeh Sarvari, Sepideh Alavi-Moghadam, Rasta Arjmand, Mostafa Rezaei-Tavirani, Ghasem Janbabaei, Mohamad Vaezi, Bagher Larijani
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引用次数: 0

摘要

造血干细胞移植是治疗血液系统恶性肿瘤和疾病的重要方法,但存在移植物抗宿主病、感染和复发等高风险。最近的证据表明,微生物组在影响移植结果中起着重要作用,其中微生物生态失调(由多样性减少和病原体过度生长定义)与更大的并发症和死亡有关。通过包括有益微生物物种、纤维、粪便移植和饮食在内的方法来控制微生物组有可能减轻这些风险。实验表明,有益微生物的恢复可以恢复免疫力,降低移植物抗宿主病的严重程度,减少感染。一些挑战仍然存在,包括方案的标准化、长期疗效和免疫功能低下受者的安全性。未来的研究将集中在微生物组治疗的机制、试验和新技术上,最终目标是提高移植受者的生存率和生活质量。因此,本文综述了微生物组工程如何通过优化肠道微生物群落,从而在造血干细胞移植(HSCT)中获得更好的结果,从而彻底改变癌症治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gut Microbiome and its Impact on Outcomes following Hematopoietic Stem Cell Transplantation: a Comprehensive Review.

Hematopoietic stem cell transplantation is an important treatment for hematological malignancy and disorders, but is fraught with high risks, including graft-versus-host disease, infection, and relapse. Recent evidence now identifies that the microbiome plays a significant role in influencing transplant outcomes, in which microbial dysbiosis-defined by reduced diversity and pathogen overgrowth-is linked to greater complications and death. Microbiome manipulation with approaches including beneficial microbial species, fiber, fecal transplants, and diet has the potential to mitigate these risks. Experiments show that the restoration of beneficial microbes can restore immunity, reduce graft-versus-host disease severity, and reduce infection. Some challenges remain, including standardization of protocols, long-term efficacy, and safety in immunocompromised recipients. Future research will be focused on mechanisms, trials, and new technology for microbiome-based therapy, with the ultimate goal of improving survival and quality of life for transplant recipients. Hereupon, this review addresses how microbiome engineering can revolutionize cancer treatment by optimizing gut microbial communities for better outcomes in hematopoietic stem cell transplantation (HSCT).

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来源期刊
Stem Cell Reviews and Reports
Stem Cell Reviews and Reports 医学-细胞生物学
CiteScore
9.30
自引率
4.20%
发文量
0
审稿时长
3 months
期刊介绍: The purpose of Stem Cell Reviews and Reports is to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal will consider for publication: i) solicited or unsolicited reviews of topical areas of stem cell biology that highlight, critique and synthesize recent important findings in the field. ii) full length and short reports presenting original experimental work. iii) translational stem cell studies describing results of clinical trials using stem cells as therapeutics. iv) papers focused on diseases of stem cells. v) hypothesis and commentary articles as opinion-based pieces in which authors can propose a new theory, interpretation of a controversial area in stem cell biology, or a stem cell biology question or paradigm. These articles contain more speculation than reviews, but they should be based on solid rationale. vi) protocols as peer-reviewed procedures that provide step-by-step descriptions, outlined in sufficient detail, so that both experts and novices can apply them to their own research. vii) letters to the editor and correspondence. In order to facilitate this exchange of scientific information and exciting novel ideas, the journal has created five thematic sections, focusing on: i) the role of adult stem cells in tissue regeneration; ii) progress in research on induced pluripotent stem cells, embryonic stem cells and mechanism governing embryogenesis and tissue development; iii) the role of microenvironment and extracellular microvesicles in directing the fate of stem cells; iv) mechanisms of stem cell trafficking, stem cell mobilization and homing with special emphasis on hematopoiesis; v) the role of stem cells in aging processes and cancerogenesis.
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