Xin Sun, Xiao-Wei Shi, Lei Han, Yi-Fan Zhang, Yang Xu, Yu-Cheng Lu
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Recent progress in the use of periplocin, periplocymarin and periplogenin in cancer treatment.
Periplocin, periplocymarin and periplogenin are the main active components of Cortex Periplocae. The most cytotoxic constituent of Cortex Periplocae, periplocin is an alpha cardiac glycoside with a steroid core and an unsaturated five-membered lactone ring structure. Periplocymarin is a secondary alpha cardiac glycoside, which is produced by removing one molecule of glucose from periplocin, and periplogenin is the glycosidic portion and the basic unit of periplocin and periplocymarin. These three cardiac glycosides, by virtue of their unique pharmacological activities and mechanisms of action, mediate signaling pathways, mainly the retinoblastoma and p53 signaling pathways, and regulate cell cycle proteins, thereby hindering the proliferation of cancer cells and altering the cell cycle process. These glycosides also regulate caspase proteins by mediating endogenous and exogenous pathways, thereby inducing the apoptosis of cancer cells. This minireview focuses on the inhibitory effects of periplocin, periplocymarin and periplogenin on cancer, and explores their potential antitumor mechanisms.
期刊介绍:
The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.