{"title":"胚胎模型的综合/非综合区分真的过时了吗?","authors":"Hafez Ismaili M'hamdi","doi":"10.1136/jme-2025-111245","DOIUrl":null,"url":null,"abstract":"<p><p>Stem cell-based embryo models (SCBEMs) offer new ways for studying early human development while circumventing ethical challenges associated with natural embryos. Traditionally, SCBEMs are categorised as 'integrated' or 'non-integrated', reflecting their capacity for coordinated development and potential to acquire morally relevant properties. However, the <i>Code of Practice</i> challenges this distinction, arguing that non-integrated SCBEMs can reach stages of significant developmental complexity, making the classification obsolete. This paper critiques the abandonment of the integrated/non-integrated framework. I argue that the distinction is tied, rightfully so, to developmental potential rather than structural complexity. For the ethical oversight of embryo models, the potential to develop morally relevant properties and thus the integrated/non-integrated distinction remains relevant.</p>","PeriodicalId":16317,"journal":{"name":"Journal of Medical Ethics","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Is the integrated/non-integrated distinction for embryo models really obsolete?\",\"authors\":\"Hafez Ismaili M'hamdi\",\"doi\":\"10.1136/jme-2025-111245\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Stem cell-based embryo models (SCBEMs) offer new ways for studying early human development while circumventing ethical challenges associated with natural embryos. Traditionally, SCBEMs are categorised as 'integrated' or 'non-integrated', reflecting their capacity for coordinated development and potential to acquire morally relevant properties. However, the <i>Code of Practice</i> challenges this distinction, arguing that non-integrated SCBEMs can reach stages of significant developmental complexity, making the classification obsolete. This paper critiques the abandonment of the integrated/non-integrated framework. I argue that the distinction is tied, rightfully so, to developmental potential rather than structural complexity. For the ethical oversight of embryo models, the potential to develop morally relevant properties and thus the integrated/non-integrated distinction remains relevant.</p>\",\"PeriodicalId\":16317,\"journal\":{\"name\":\"Journal of Medical Ethics\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Medical Ethics\",\"FirstCategoryId\":\"98\",\"ListUrlMain\":\"https://doi.org/10.1136/jme-2025-111245\",\"RegionNum\":2,\"RegionCategory\":\"哲学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ETHICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Ethics","FirstCategoryId":"98","ListUrlMain":"https://doi.org/10.1136/jme-2025-111245","RegionNum":2,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ETHICS","Score":null,"Total":0}
Is the integrated/non-integrated distinction for embryo models really obsolete?
Stem cell-based embryo models (SCBEMs) offer new ways for studying early human development while circumventing ethical challenges associated with natural embryos. Traditionally, SCBEMs are categorised as 'integrated' or 'non-integrated', reflecting their capacity for coordinated development and potential to acquire morally relevant properties. However, the Code of Practice challenges this distinction, arguing that non-integrated SCBEMs can reach stages of significant developmental complexity, making the classification obsolete. This paper critiques the abandonment of the integrated/non-integrated framework. I argue that the distinction is tied, rightfully so, to developmental potential rather than structural complexity. For the ethical oversight of embryo models, the potential to develop morally relevant properties and thus the integrated/non-integrated distinction remains relevant.
期刊介绍:
Journal of Medical Ethics is a leading international journal that reflects the whole field of medical ethics. The journal seeks to promote ethical reflection and conduct in scientific research and medical practice. It features articles on various ethical aspects of health care relevant to health care professionals, members of clinical ethics committees, medical ethics professionals, researchers and bioscientists, policy makers and patients.
Subscribers to the Journal of Medical Ethics also receive Medical Humanities journal at no extra cost.
JME is the official journal of the Institute of Medical Ethics.