来自微藻的类生物维生素a:提高视黄醇性能和耐受性。

IF 2.5 4区 医学 Q2 DERMATOLOGY
Silvia Sánchez-Díez, Alexandre Lapeyre, Noemí García-Delgado, Jordi Ayats
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引用次数: 0

摘要

目的:皮肤老化,色素沉着和纹理是常见的皮肤病学问题。类维生素a,包括视黄醇,因其治疗这些疾病的功效而被广泛使用。然而,它们的副作用,如刺激,往往限制了它们的使用。Bakuchiol是一种植物衍生的类维甲酸替代品,因其温和的特性而受到关注,但其功效仍然是与传统类维甲酸进行比较的主题。本研究的目的是评估一种新型微藻衍生的生物类维甲酸(MBR)在促进皮肤再生、减少衰老迹象和解决色素沉着方面的功效,与视黄醇和bakuchiol进行比较。方法:体外观察MBR对细胞增殖、黑色素生成和细胞外基质调节的影响。在临床上,与参考治疗相比,MBR应用于评估皮肤质地、紧致度、弹性和色素沉着的改善。结果:在体外,MBR在细胞增殖、黑色素减少和ECM调节方面明显优于视黄醇和bakuchiol。在体内,MBR改善了皮肤质地、紧致度和色素沉着,其结果与视黄醇相当。MBR还协同增强视黄醇的作用,改善水合作用,减少刺激。结论:MBR是一种很有前景的替代传统类维生素a的方法,在皮肤再生和色素沉着控制方面具有更强的功效,并且更有利的安全性,特别是与视黄醇联合使用时。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bioretinoids from microalgae: Boosting retinol performance and tolerability.

Objective: Skin ageing, hyperpigmentation, and texture are common dermatological concerns. Retinoids, including retinol, are widely used for their efficacy in treating these conditions. However, their side effects, such as irritation, often limit their use. Bakuchiol, a plant-derived retinoid alternative, has gained attention for its gentler profile, but its efficacy remains a subject of comparison with traditional retinoids. The aim of the present study was to evaluate the efficacy of a novel microalgae-derived bioretinoid (MBR) in comparison to retinol and bakuchiol in promoting skin regeneration, reducing ageing signs, and addressing hyperpigmentation.

Methods: The effects of MBR were evaluated in vitro for cell proliferation, melanin production, and extracellular matrix modulation. Clinically, MBR was applied to assess improvements in skin texture, firmness, elasticity, and pigmentation compared with reference treatments.

Results: In vitro, MBR significantly outperformed both retinol and bakuchiol in cell proliferation, melanin reduction, and ECM modulation. In vivo, MBR improved skin texture, firmness, and pigmentation, showing results comparable to retinol. MBR also synergistically enhanced retinol's effects, improving hydration and reducing irritation.

Conclusion: MBR is a promising alternative to traditional retinoids, offering enhanced efficacy in skin regeneration and pigmentation control with a more favourable safety profile, especially when combined with retinol.

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来源期刊
CiteScore
4.60
自引率
4.30%
发文量
73
期刊介绍: The Journal publishes original refereed papers, review papers and correspondence in the fields of cosmetic research. It is read by practising cosmetic scientists and dermatologists, as well as specialists in more diverse disciplines that are developing new products which contact the skin, hair, nails or mucous membranes. The aim of the Journal is to present current scientific research, both pure and applied, in: cosmetics, toiletries, perfumery and allied fields. Areas that are of particular interest include: studies in skin physiology and interactions with cosmetic ingredients, innovation in claim substantiation methods (in silico, in vitro, ex vivo, in vivo), human and in vitro safety testing of cosmetic ingredients and products, physical chemistry and technology of emulsion and dispersed systems, theory and application of surfactants, new developments in olfactive research, aerosol technology and selected aspects of analytical chemistry.
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