各种皮肤脂质成分及其结构衍生物对皮肤屏障损伤的恢复作用。

IF 2.5 4区 医学 Q2 DERMATOLOGY
Sang Gwon Seo, Tae Geun Kwon, Ji Won Ha, Jooyoung Oh, Moon Joo Kim, Sohyun In
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引用次数: 0

摘要

目的:神经酰胺(CERs)等皮肤脂质在维持皮肤屏障中起重要作用。虽然cer的益处是众所周知的,但很少有研究调查其他皮肤脂质成分对皮肤屏障的影响。因此,本研究比较了几种皮肤脂质成分及其结构衍生物(包括cer)对皮肤屏障的作用。方法:测定不同脂质成分面霜的保水性和封闭系数,分别评价其保湿效果和封闭效果。使用十二烷基硫酸钠(SDS)诱导皮肤损伤的人体研究也进行了探讨皮肤屏障恢复。用超声仪测定表皮厚度和密度。结果:含褪黑酸(BA)的乳膏保水能力最好,含CER和BA的乳膏明显增加了闭塞因子。在小角度x射线散射分析中,含ba乳膏呈立方结构,这可能是高遮挡因子的原因。在sds损伤的皮肤中,与未处理的皮肤相比,使用含有BA和CER的乳膏处理的皮肤区域经皮失水恢复明显更快。结论:本研究比较了皮肤脂质成分的皮肤屏障恢复效果,表明BA具有与CER相似的高皮肤屏障恢复效果,具有已知的功效。BA通过脂质包装也具有良好的密封效果,而CER具有复合密封效果,增加了表皮厚度和密度。这些结果为配方产品提供了基础证据,这些产品通过向皮肤表面提供脂质来帮助恢复皮肤屏障。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recovery effects of various skin lipid components and their structural derivatives on skin barrier damage.

Objective: Skin lipids, such as ceramides (CERs), play an important role in maintaining the skin barrier. Although the benefits of CERs are well known, few studies have investigated the effects of other skin lipid components on the skin barrier. Therefore, this study compared the efficacy of several skin lipid components and their structural derivatives, including CERs, on the skin barrier.

Methods: The water-holding capacity and occlusion factor were determined to evaluate the moisture barrier and sealing effects, respectively, of creams containing various skin lipid components. A human study using sodium dodecyl sulfate (SDS) to induce skin damage was also conducted to explore skin barrier recovery. Epidermal thickness and density were measured using an ultrasonic instrument.

Results: The cream containing behenic acid (BA) had the best water-holding capacity, and the creams with CER and BA significantly increased the occlusion factor. The BA-containing cream had a cubic structural pattern in the small-angle X-ray scattering analysis, which may explain the high occlusion factor. In SDS-damaged skin, transepidermal water loss recovered significantly faster in skin areas treated with cream containing BA and CER compared with non-treated skin.

Conclusion: This study compares the skin barrier recovery effects of skin lipid components, demonstrating that BA elicits a high skin barrier recovery effect similar to that of CER, which has known efficacy. BA also had an excellent sealing effect through lipid packaging, whereas CER had a combined sealing effect and increased the epidermal thickness and density. These results provide foundational evidence for formulating products that help restore the skin barrier by supplying lipids to the skin surface.

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来源期刊
CiteScore
4.60
自引率
4.30%
发文量
73
期刊介绍: The Journal publishes original refereed papers, review papers and correspondence in the fields of cosmetic research. It is read by practising cosmetic scientists and dermatologists, as well as specialists in more diverse disciplines that are developing new products which contact the skin, hair, nails or mucous membranes. The aim of the Journal is to present current scientific research, both pure and applied, in: cosmetics, toiletries, perfumery and allied fields. Areas that are of particular interest include: studies in skin physiology and interactions with cosmetic ingredients, innovation in claim substantiation methods (in silico, in vitro, ex vivo, in vivo), human and in vitro safety testing of cosmetic ingredients and products, physical chemistry and technology of emulsion and dispersed systems, theory and application of surfactants, new developments in olfactive research, aerosol technology and selected aspects of analytical chemistry.
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