{"title":"利用MRI揭示心血管系统对脑血管健康的影响。","authors":"Ian D Driver, Kevin Murphy","doi":"10.1113/EP092467","DOIUrl":null,"url":null,"abstract":"<p><p>Human cerebrovasculature is finely tuned to enable local changes in blood flow to meet the brain's demands, whilst protecting the brain from systemic changes in blood pressure, both acutely during a heartbeat and chronically over time. This review summarises cerebrovascular structure and function, their role in disease and neurodegeneration and the part MRI measurements can play in probing them. MRI methods to measure various aspects of cerebrovascular physiology are described and placed in context of applications studying cerebrovascular health. The role of the cardiovascular system linking the cardiac pulse wave to cerebrovascular disease and gaps in mechanistic knowledge are highlighted.</p>","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI.\",\"authors\":\"Ian D Driver, Kevin Murphy\",\"doi\":\"10.1113/EP092467\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Human cerebrovasculature is finely tuned to enable local changes in blood flow to meet the brain's demands, whilst protecting the brain from systemic changes in blood pressure, both acutely during a heartbeat and chronically over time. This review summarises cerebrovascular structure and function, their role in disease and neurodegeneration and the part MRI measurements can play in probing them. MRI methods to measure various aspects of cerebrovascular physiology are described and placed in context of applications studying cerebrovascular health. The role of the cardiovascular system linking the cardiac pulse wave to cerebrovascular disease and gaps in mechanistic knowledge are highlighted.</p>\",\"PeriodicalId\":12092,\"journal\":{\"name\":\"Experimental Physiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental Physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1113/EP092467\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1113/EP092467","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI.
Human cerebrovasculature is finely tuned to enable local changes in blood flow to meet the brain's demands, whilst protecting the brain from systemic changes in blood pressure, both acutely during a heartbeat and chronically over time. This review summarises cerebrovascular structure and function, their role in disease and neurodegeneration and the part MRI measurements can play in probing them. MRI methods to measure various aspects of cerebrovascular physiology are described and placed in context of applications studying cerebrovascular health. The role of the cardiovascular system linking the cardiac pulse wave to cerebrovascular disease and gaps in mechanistic knowledge are highlighted.
期刊介绍:
Experimental Physiology publishes research papers that report novel insights into homeostatic and adaptive responses in health, as well as those that further our understanding of pathophysiological mechanisms in disease. We encourage papers that embrace the journal’s orientation of translation and integration, including studies of the adaptive responses to exercise, acute and chronic environmental stressors, growth and aging, and diseases where integrative homeostatic mechanisms play a key role in the response to and evolution of the disease process. Examples of such diseases include hypertension, heart failure, hypoxic lung disease, endocrine and neurological disorders. We are also keen to publish research that has a translational aspect or clinical application. Comparative physiology work that can be applied to aid the understanding human physiology is also encouraged.
Manuscripts that report the use of bioinformatic, genomic, molecular, proteomic and cellular techniques to provide novel insights into integrative physiological and pathophysiological mechanisms are welcomed.