C1q/ tnf相关蛋白3 （CTRP3）在人类疾病中的多功能作用及治疗前景

IF 1.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current Medical Science Pub Date : 2025-09-04 DOI:10.1007/s11596-025-00075-7

Qing-Peng Wang, Chen Wang, Yan-Hong Yuan, Yun Yang, Rui Tian, Jiang-Yang Chi, Xin-Zhong Chen

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引用次数: 0

摘要

脂肪因子，包括C1q/肿瘤坏死因子（TNF）相关蛋白（CTRPs）、脂联素、TNF-α和瘦素，是由脂肪组织分泌并在血液中循环的重要生物活性分子。迄今为止，已经确定了CTRP家族的15个成员，这些成员统称为C1q/TNF超家族的一部分。其中，CTRP3因其独特的结构和功能特性而成为一种独特的脂肪因子。近年来的研究强调了CTRP3在多种疾病发病机制中的重要作用。本文旨在全面总结CTRP3在多种疾病发展中的作用及其机制，以及其潜在的治疗意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Multifunctional Roles and Therapeutic Prospects of C1q/TNF-Related Protein 3 (CTRP3) in Human Diseases.

Adipokines, including C1q/tumor necrosis factor (TNF)-related proteins (CTRPs), adiponectin, TNF-α, and leptin, are crucial bioactive molecules that are secreted by adipose tissue and circulate in the bloodstream. To date, 15 members of the CTRP family, which are collectively classified as part of the C1q/TNF superfamily, have been identified. Among these, CTRP3 stands out as a unique adipokine because of its distinct structural and functional properties. Recent research has highlighted the significant role of CTRP3 in the pathogenesis of various diseases. This review aims to comprehensively summarize the involvement and mechanisms of CTRP3 in the development of numerous disorders, as well as its potential therapeutic implications.

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来源期刊

Current Medical Science Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

4.70

自引率

0.00%

发文量

126

期刊介绍： Current Medical Science provides a forum for peer-reviewed papers in the medical sciences, to promote academic exchange between Chinese researchers and doctors and their foreign counterparts. The journal covers the subjects of biomedicine such as physiology, biochemistry, molecular biology, pharmacology, pathology and pathophysiology, etc., and clinical research, such as surgery, internal medicine, obstetrics and gynecology, pediatrics and otorhinolaryngology etc. The articles appearing in Current Medical Science are mainly in English, with a very small number of its papers in German, to pay tribute to its German founder. This journal is the only medical periodical in Western languages sponsored by an educational institution located in the central part of China.