酮体对骨骼肌的合成代谢和抗代谢作用:与骨骼肌萎缩管理的潜在相关性。

IF 3.5 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Tyler A Churchward-Venne
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引用次数: 0

摘要

综述目的:骨骼肌损失是衰老、疾病和缺乏运动的标志,很少有有效的治疗方法。酮体是脂质衍生分子,其内源性生产在碳水化合物剥夺的条件下(如禁食,生酮饮食)大大增加。口服的酮类补充剂现在可以在不限制饮食碳水化合物的情况下迅速诱导持续数小时的明显酮症状态。从历史上看,酮体被假设为在饥饿期间节省肌肉蛋白质。最近,它们对骨骼肌的潜在合成代谢和抗代谢作用获得了新的研究和临床兴趣。本文综述了酮体给药及其对骨骼肌蛋白转换和相关信号传导的影响的新证据,并考虑了在肌肉萎缩和康复中的治疗应用。最近的发现:口服酮补充剂已被证明可以增强健康年轻男性餐后肌肉蛋白合成(MPS)。在炎症分解代谢条件下,酮体也可能通过抑制肌肉蛋白分解(MPB)来促进有利的净蛋白平衡。总结:酮体可以减弱MPB并刺激MPS,提示在对抗肌肉萎缩方面的潜在效用。然而,需要进一步的研究来阐明潜在的机制,并在临床环境中评估对肌肉质量和功能的长期影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anabolic and anticatabolic actions of ketone bodies on skeletal muscle: potential relevance in the management of skeletal muscle wasting.

Purpose of review: Skeletal muscle loss is a hallmark of aging, disease, and physical inactivity, with few effective treatments. Ketone bodies are lipid-derived molecules whose endogenous production is substantially amplified under conditions characterized by carbohydrate deprivation (e.g. fasting, a ketogenic diet). Orally ingested ketone supplements are now available that can rapidly induce a pronounced state of ketosis lasting hours without dietary carbohydrate restriction. Historically, ketone bodies have been hypothesized to spare muscle protein during starvation. Recently, their potential anabolic and anticatabolic effects on skeletal muscle have garnered renewed research and clinical interest. This review examines emerging evidence on ketone body administration and its influence on skeletal muscle protein turnover and related signaling, with consideration for therapeutic application in muscle wasting and rehabilitation.

Recent findings: Oral ketone supplementation has been shown to enhance postprandial muscle protein synthesis (MPS) in healthy young males. Under inflammatory catabolic conditions, ketone bodies may also promote a favorable net protein balance via suppression of muscle protein breakdown (MPB).

Summary: Ketone body administration may attenuate MPB and stimulate MPS, suggesting potential utility in counteracting muscle wasting. However, further studies are needed to elucidate underlying mechanisms and assess long-term effects on muscle mass and function in clinical settings.

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来源期刊
CiteScore
5.30
自引率
6.50%
发文量
116
审稿时长
6-12 weeks
期刊介绍: A high impact review journal which boasts an international readership, Current Opinion in Clinical Nutrition and Metabolic Care offers a broad-based perspective on the most recent and exciting developments within the field of clinical nutrition and metabolic care. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include protein, amino acid metabolism and therapy, lipid metabolism and therapy, nutrition and the intensive care unit and carbohydrates. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.
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