秘鲁利马健康儿童中金黄色葡萄球菌和肺炎链球菌定植动态的抗生素耐药性和相关因素

IF 2.2 4区 医学 Q3 INFECTIOUS DISEASES
Valeria Mariana Li Valverde, Paulo Cesar Aguirre Castañeda, Brayan E Gonzales, Franco Castillo-Tokumori, Jorge E Vidal, Theresa J Ochoa
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引用次数: 0

摘要

肺炎球菌结合疫苗(PCVs)影响了鼻咽部肺炎链球菌的种群动态,并可能导致金黄色葡萄球菌定植增加。本研究评估了pcv引入后秘鲁健康儿童中金黄色葡萄球菌和肺炎葡萄球菌定植和共定植的流行情况、抗生素耐药性模式以及相关危险因素。儿童鼻咽拭子金黄色葡萄球菌,20.3%与肺炎葡萄球菌,2.9%共定植。在分离的176株金黄色葡萄球菌中,1.7%对甲氧西林耐药,20.5%对克林霉素耐药;对甲氧苄啶-磺胺甲恶唑(SXT)无耐药性。182株肺炎链球菌对大环内酯类耐药48.9%,对SXT耐药74.7%;未发现对青霉素有耐药性。母乳喂养和PCV13疫苗接种与金黄色葡萄球菌定植率降低相关,而PCV13疫苗接种增加了肺炎葡萄球菌定植率,主要是通过非疫苗血清型。这项研究强调需要继续监测疫苗引入后定植动态和抗微生物药物耐药性模式的变化,以指导经验性治疗和未来的疫苗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antibiotic resistance and factors associated with colonization dynamics of Staphylococcus aureus and Streptococcus pneumoniae in healthy children in Lima, Peru.

Pneumococcal conjugate vaccines (PCVs) have influenced population dynamics of Streptococcus pneumoniae in the nasopharynx and may have contributed to increased Staphylococcus aureus colonization. This study assessed the prevalence of colonization, antibiotic resistance patterns, and associated risk factors for colonization and co-colonization of S. aureus and S. pneumoniae in healthy Peruvian children post-PCV introduction. Nasopharyngeal swabs from children <24 months were collected in five hospitals in Lima (2018-2019). Microbiological identification and antibiotic susceptibility tests were performed, and multinomial regression evaluated factors influencing colonization. Among 894 children, 19.7% were colonized with S. aureus, 20.3% with S. pneumoniae, and 2.9% co-colonized. Of the 176 S. aureus strains isolated, 1.7% were methicillin resistant and 20.5% were clindamycin resistant; no resistance to trimethoprim-sulfamethoxazole (SXT) was found. Among 182 S. pneumoniae strains isolated, 48.9% were resistant to macrolides, 74.7% to SXT; no resistance to penicillin was found. Breastfeeding and vaccination with PCV13 were associated with a reduced prevalence of S. aureus colonization, while vaccination with PCV13 increased the prevalence of S. pneumoniae colonization, mainly by non-vaccine serotypes. This study highlights the need to continue monitoring the changes in colonization dynamics and antimicrobial resistance patterns after vaccine introduction, to guide empirical therapy and future vaccine strategies.

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来源期刊
Epidemiology and Infection
Epidemiology and Infection 医学-传染病学
CiteScore
4.10
自引率
2.40%
发文量
366
审稿时长
3-6 weeks
期刊介绍: Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.
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