Metachronous Bilateral Nephrectomy, Supratrigonal Cystectomy, and Living Donor Renal Transplantation in a Patient With Chronic Kidney Disease due to Interstitial Cystitis and Total Urethral Stricture.

Introduction: Interstitial cystitis (IC) is a chronic pelvic pain syndrome characterized by urinary urgency, frequency, and pain. Although the exact cause of IC is unclear, severe cases may lead to chronic kidney disease (CKD), requiring complex surgical interventions. Case Presentation: This case report presents a 46-year-old male with IC complicated by CKD secondary to total urethral stricture. Following recurrent surgeries for urinary tract infections and strictures, the patient underwent a staged surgical approach involving bilateral nephrectomy, supratrigonal cystectomy, and renal transplantation with Bricker ileal conduit diversion. Postoperatively, renal function was fully restored, and IC-related symptoms resolved. Conclusion: This case underscores the efficacy of major surgical interventions for refractory IC, highlighting the need for individualized, multidisciplinary management in complex cases.