胰岛素样生长因子模拟材料的研究进展。

IF 2.6 3区 生物学 Q3 MATERIALS SCIENCE, BIOMATERIALS
Abhishek Roy, Joseph B Dodd-O, Bobak Shadpoor, Siya K Patel, Gelavizh Gharati, Marleen Hanna, Abdul Lateef-Fnu, Corey Heffernan, Vivek A Kumar
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引用次数: 0

摘要

生长因子在调节细胞增殖、分化和存活等过程中起着至关重要的作用。它们的活动受到严格调节,以确保正常的生理功能,而失调往往有助于疾病的发病机制。其中,包含IGF-1和IGF受体结合蛋白的胰岛素样生长因子(IGF)系统在通过调节生长、修复和代谢调节来维持整体细胞健康方面起着关键作用。利用IGF-1的促有丝分裂作用,转化研究一直致力于开发基于IGF-1的治疗方法,以治疗与年龄相关的肌肉损失、代谢紊乱或心血管疾病。模拟肽设计已成为克服直接IGF-1治疗局限性的一种创新方法,其重点是结构优化以提高生物利用度、稳定性和受体特异性。本文就IGF-1模拟物的研究进展及其潜在的临床应用进行综述。描述了它们的设计和分子特性,包括结构考虑和作用机制。在体外和体内的方法分析,以提供深入了解他们的药代动力学,治疗效果,并在动物模型的安全性概况将深入研究。这些临床前研究揭示了IGF-1模拟物的优势,如生物利用度、稳定性和递送,以及局限性,包括潜在的免疫原性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of Insulin-Like Growth Factor Mimetic Materials.

Growth factors play a crucial role in regulating cellular processes such as proliferation, differentiation, and survival. Their activities are tightly modulated to ensure proper physiological functioning, with dysregulation often contributing to disease pathogenesis. Among these, the insulin-like growth factor (IGF) system that encompasses IGF-1 and IGF-receptor binding proteins is pivotal in maintaining overall cellular health by regulating growth, repair, and metabolic regulation. Capitalizing on its pro-mitogenic effects, translational studies have focused efforts on developing therapeutics based on IGF-1 for age-related muscle loss, metabolic disorders, or cardiovascular diseases. Mimetic peptide design has emerged as an innovative approach to overcoming limitations of direct IGF-1 therapy, focusing on structural optimization to enhance bioavailability, stability, and receptor specificity. Herein, the development of IGF-1 mimics and their potential clinical applications are reviewed. Their design and molecular properties, including structural considerations and mechanisms of action, are described. In vitro and in vivo approaches analyzed to provide insights into their pharmacokinetics, therapeutic efficacy, and safety profiles in animal models will be delved into. These preclinical studies shed light on the advantages of IGF-1 mimics, such as bioavailability, stability, and delivery, as well as the limitations, including potential immunogenicity.

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来源期刊
Advanced biology
Advanced biology Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
6.60
自引率
0.00%
发文量
130
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