鼠与人牙本质-牙釉质连接的多模态比较。

IF 1.4 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Acta biochimica Polonica Pub Date : 2025-08-18 eCollection Date: 2025-01-01 DOI:10.3389/abp.2025.14642
Michael Truhlar, Sobhan Katebifar, Bradley Rosenberg, Roland Kroger, Alix C Deymier
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引用次数: 0

摘要

人和老鼠的门牙都主要由牙本质和牙釉质组成,它们在一个叫做牙本质-牙釉质交界处(DEJ)的界面上相遇。然而,这两个物种的门牙有非常不同的生长模式、结构和负荷要求。由于DEJ负责在机械上不同的牙本质和牙釉质之间的危险界面上最大限度地减少开裂,因此其结构预计在人类和小鼠之间存在显着差异。在这里,通过微计算机断层扫描和拉曼光谱测量了人类和小鼠门牙DEJs的结构和成分梯度。与老鼠牙齿相比,人类牙齿上的密度梯度明显更大,可能是由于地幔牙本质的尺寸更大。在小鼠DEJ中发现了矿物含量和结晶度的多重梯度,而在人类DEJ中只存在矿物含量的梯度。根据成分结果预测跨DEJ的模量的模型表明,矿物结晶度在调节跨DEJ的组织刚度梯度方面是至关重要的。总之,这些结果表明了DEJ可以适应载荷环境变化的多种方式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Multi-modal comparison of murine and human incisal dentin-enamel junctions.

Multi-modal comparison of murine and human incisal dentin-enamel junctions.

Multi-modal comparison of murine and human incisal dentin-enamel junctions.

Multi-modal comparison of murine and human incisal dentin-enamel junctions.

Human and mouse incisors are both primarily composed of dentin and enamel, which meet at an interface called the dentin-enamel junction (DEJ). However, incisors in the two species have very different growth patterns, structures, and loading requirements. Since the DEJ is responsible for minimizing cracking at this at-risk interface between mechanically dissimilar dentin and enamel, its structure is expected to be significantly different between humans and mice. Here, structural and compositional gradients across human and murine incisors DEJs were measured via microcomputed tomography and Raman spectroscopy. Density gradients across the DEJ were significantly larger in humans compared to murine teeth, likely due to the larger size of the mantle dentin. Multiple gradients in mineral content and crystallinity were found at the murine DEJ, while the human DEJ only exhibited gradients in mineral content. Models predicting the modulus across the DEJ according to compositional results show that mineral crystallinity is critical in regulating gradients in tissue stiffness across the murine DEJ. Together, these results show the multiple ways in which the DEJ can adapt to variations in the loading environment.

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来源期刊
Acta biochimica Polonica
Acta biochimica Polonica 生物-生化与分子生物学
CiteScore
2.40
自引率
0.00%
发文量
99
审稿时长
4-8 weeks
期刊介绍: Acta Biochimica Polonica is a journal covering enzymology and metabolism, membranes and bioenergetics, gene structure and expression, protein, nucleic acid and carbohydrate structure and metabolism.
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