街头毒品样品中美托咪定对映体的测定(2024年8月- 2025年2月)及其对免疫测定试纸条分析的影响。

IF 2.7 3区 医学 Q2 BIOCHEMICAL RESEARCH METHODS
Edward Sisco, Mónica Ventura, Sarah A Shuda
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引用次数: 0

摘要

在过去的几年里,α - 2激动剂大量流入街头药物供应,首先是强效兽药噻嗪的大量使用。自2023年以来,另一种镇静剂美托咪定也被广泛检测到。美托咪定,广义上包括两种对映体——右美托咪定和左美托咪定,右美托咪定对映体具有药理活性,存在于人类使用的药物中。在这项工作中,我们调查了含有美托咪定的街头毒品样本,以更好地了解非法供应中的对映体组成。采用液相色谱串联质谱法(LC-MS/MS)对100份药品或随身用品残留样品进行了分析。所有样品都含有美托咪定的外消旋混合物。用美托咪定免疫测定试纸分析了一部分样品,其中外消旋混合物未发现对结果有负面影响。所有样品还使用实时质谱(DART-MS)直接分析进行定性分析,以鉴定常见的共发生化合物,包括芬太尼、噻嗪和局部麻醉剂。在合法注射制剂中未检出防腐剂对羟基苯甲酸酯。这项工作为街头药物供应的美托咪定组成提供了一个快照,鉴于两种对映体之间的药理学差异,需要持续监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enantiomeric Determination of Medetomidine in Street Drug Samples (August 2024-February 2025) and Implications for Immunoassay Test Strip Analysis.

Over the last several years, there has been an influx of α2-agonists into the street drug supply, beginning with the proliferation of xylazine, a potent veterinary sedative. Since 2023, another sedative, medetomidine, has been widely detected. Medetomidine, broadly, encompasses two enantiomers-dexmedetomidine and levomedetomidine-with the dex enantiomer being pharmacologically active and present in human-use pharmaceuticals. In this work, we investigate street drug samples containing medetomidine to better understand the enantiomeric makeup in the illicit supply. Liquid chromatography tandem mass spectrometry (LC-MS/MS) was used to analyze 100 drug product or paraphernalia residue samples. All samples were found to contain a racemic mixture of medetomidine. A subset of samples was analyzed by medetomidine immunoassay test strips, where racemic mixtures were not found to negatively affect results. All samples were also qualitatively analyzed using direct analysis in real time mass spectrometry (DART-MS) to identify commonly co-occurring compounds, which included fentanyl, xylazine, and local anesthetics. Parabens, preservatives found in licit injectable preparations of the drug, were not detected. This work provides a snapshot into the medetomidine makeup of the street drug supply, which needs to be continually monitored given the differences in pharmacology between the two enantiomers.

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来源期刊
Drug Testing and Analysis
Drug Testing and Analysis BIOCHEMICAL RESEARCH METHODS-CHEMISTRY, ANALYTICAL
CiteScore
5.90
自引率
24.10%
发文量
191
审稿时长
2.3 months
期刊介绍: As the incidence of drugs escalates in 21st century living, their detection and analysis have become increasingly important. Sport, the workplace, crime investigation, homeland security, the pharmaceutical industry and the environment are just some of the high profile arenas in which analytical testing has provided an important investigative tool for uncovering the presence of extraneous substances. In addition to the usual publishing fare of primary research articles, case reports and letters, Drug Testing and Analysis offers a unique combination of; ‘How to’ material such as ‘Tutorials’ and ‘Reviews’, Speculative pieces (‘Commentaries’ and ‘Perspectives'', providing a broader scientific and social context to the aspects of analytical testing), ‘Annual banned substance reviews’ (delivering a critical evaluation of the methods used in the characterization of established and newly outlawed compounds). Rather than focus on the application of a single technique, Drug Testing and Analysis employs a unique multidisciplinary approach to the field of controversial compound determination. Papers discussing chromatography, mass spectrometry, immunological approaches, 1D/2D gel electrophoresis, to name just a few select methods, are welcomed where their application is related to any of the six key topics listed below.
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