简化心脏组织模型中螺旋波的比较

IF 1.3 4区 物理与天体物理 Q3 PHYSICS, MULTIDISCIPLINARY
S. Mohanty, D. Prusty, A. R. Nayak
{"title":"简化心脏组织模型中螺旋波的比较","authors":"S. Mohanty,&nbsp;D. Prusty,&nbsp;A. R. Nayak","doi":"10.1134/S0021364025600053","DOIUrl":null,"url":null,"abstract":"<p>Spiral waves of electrical activation in cardiac tissue can lead to life-threatening arrhythmias; therefore, understanding the mechanisms underlying the formation and propagation of spiral waves is of great interest in cardiac dynamics. In this study, we conduct a comparative analysis of spiral waves using two simplified component models for cardiac tissue: (a) the Panfilov model and (b) the Aliev–Panfilov model, by varying the parameters that govern excitability and recovery in both models. From our numerical studies, we observe states of (i) a periodic spiral, (ii) a quasi-periodic spiral, and (iii) spiral turbulence in both models, depending on the parameters. Our systematic study reveals that the Panfilov model exhibits conduction velocity restitution behavior and spiral transition sequences that closely resemble those observed in biophysical models; thus, it is better suited for studying wave dynamics in cardiac tissue compared to the Aliev–Panfilov model, providing an alternative to computationally expensive cardiac tissue models.</p>","PeriodicalId":604,"journal":{"name":"JETP Letters","volume":"122 2","pages":"121 - 131"},"PeriodicalIF":1.3000,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1134/S0021364025600053.pdf","citationCount":"0","resultStr":"{\"title\":\"Comparison of Spiral Waves in Simplified Cardiac Tissue Models\",\"authors\":\"S. Mohanty,&nbsp;D. Prusty,&nbsp;A. R. Nayak\",\"doi\":\"10.1134/S0021364025600053\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Spiral waves of electrical activation in cardiac tissue can lead to life-threatening arrhythmias; therefore, understanding the mechanisms underlying the formation and propagation of spiral waves is of great interest in cardiac dynamics. In this study, we conduct a comparative analysis of spiral waves using two simplified component models for cardiac tissue: (a) the Panfilov model and (b) the Aliev–Panfilov model, by varying the parameters that govern excitability and recovery in both models. From our numerical studies, we observe states of (i) a periodic spiral, (ii) a quasi-periodic spiral, and (iii) spiral turbulence in both models, depending on the parameters. Our systematic study reveals that the Panfilov model exhibits conduction velocity restitution behavior and spiral transition sequences that closely resemble those observed in biophysical models; thus, it is better suited for studying wave dynamics in cardiac tissue compared to the Aliev–Panfilov model, providing an alternative to computationally expensive cardiac tissue models.</p>\",\"PeriodicalId\":604,\"journal\":{\"name\":\"JETP Letters\",\"volume\":\"122 2\",\"pages\":\"121 - 131\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1134/S0021364025600053.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JETP Letters\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S0021364025600053\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHYSICS, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JETP Letters","FirstCategoryId":"101","ListUrlMain":"https://link.springer.com/article/10.1134/S0021364025600053","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHYSICS, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

摘要

心脏组织电激活的螺旋波可导致危及生命的心律失常;因此,了解螺旋波形成和传播的机制对心脏动力学具有重要意义。在这项研究中,我们通过改变两个模型中控制兴奋性和恢复的参数,使用两个简化的心脏组织分量模型(a) Panfilov模型和(b) Aliev-Panfilov模型)对螺旋波进行了比较分析。从我们的数值研究中,我们观察到两个模型中(i)周期螺旋,(ii)准周期螺旋和(iii)螺旋湍流的状态,取决于参数。我们的系统研究表明,Panfilov模型表现出与生物物理模型非常相似的传导速度恢复行为和螺旋转变序列;因此,与Aliev-Panfilov模型相比,它更适合于研究心脏组织中的波动动力学,为计算昂贵的心脏组织模型提供了一种替代方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of Spiral Waves in Simplified Cardiac Tissue Models

Spiral waves of electrical activation in cardiac tissue can lead to life-threatening arrhythmias; therefore, understanding the mechanisms underlying the formation and propagation of spiral waves is of great interest in cardiac dynamics. In this study, we conduct a comparative analysis of spiral waves using two simplified component models for cardiac tissue: (a) the Panfilov model and (b) the Aliev–Panfilov model, by varying the parameters that govern excitability and recovery in both models. From our numerical studies, we observe states of (i) a periodic spiral, (ii) a quasi-periodic spiral, and (iii) spiral turbulence in both models, depending on the parameters. Our systematic study reveals that the Panfilov model exhibits conduction velocity restitution behavior and spiral transition sequences that closely resemble those observed in biophysical models; thus, it is better suited for studying wave dynamics in cardiac tissue compared to the Aliev–Panfilov model, providing an alternative to computationally expensive cardiac tissue models.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
JETP Letters
JETP Letters 物理-物理:综合
CiteScore
2.40
自引率
30.80%
发文量
164
审稿时长
3-6 weeks
期刊介绍: All topics of experimental and theoretical physics including gravitation, field theory, elementary particles and nuclei, plasma, nonlinear phenomena, condensed matter, superconductivity, superfluidity, lasers, and surfaces.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信