应用改进的MALDI-TOF质谱文库进行SBSEC亚种鉴定

IF 1.8 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2025-08-30 DOI:10.1016/j.diagmicrobio.2025.117094

Schawanya Kaewpitoon Rattanapitoon, Nathkapach Kaewpitoon Rattanapitoon

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引用次数: 0

摘要

Öberg等人最近的一篇文章报道了新的MALDI-TOF质谱文库的创建和验证，该文库用于牛链球菌/马链球菌复合体（SBSEC）亚种鉴定，适用于诊断培养和提取条件。他们的sbseccmr - bae库展示了近乎完美的识别性能，超过了Bruker MBT Compass和之前基于broth的库。这封信强调了他们工作的优势，将其与其他MALDI-TOF MS数据库改进研究进行了比较，并讨论了其直接的临床适用性和局限性。我们赞扬他们开发了一种实用的工具，促进了SBSEC亚种水平的准确诊断，有可能改善细菌性贫血患者心内膜炎和结直肠癌的风险分层。

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Implementation of improved MALDI-TOF MS libraries for SBSEC subspecies identification in clinical practice

The recent article by Öberg et al. reports the creation and validation of novel MALDI-TOF MS libraries for Streptococcus bovis/Streptococcus equinus-complex (SBSEC) subspecies identification adapted to diagnostic culturing and extraction conditions. Their SBSECCMRS-BAE library demonstrated near-perfect identification performance, surpassing the Bruker MBT Compass and prior broth-based libraries. This letter highlights the strengths of their work, compares it with other MALDI-TOF MS database refinement studies, and discusses its immediate clinical applicability and limitations. We commend their development of a practical tool facilitating accurate SBSEC subspecies-level diagnostics, potentially improving endocarditis and colorectal cancer risk stratification in bacteremic patients.

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.