使用双能x线吸收仪评估与放射照相膝骨关节炎相关的骨形状和排列变化：来自英国生物银行19053人的研究结果

IF 2.8

Osteoarthritis and cartilage open Pub Date : 2025-08-21 DOI:10.1016/j.ocarto.2025.100667

Rhona A. Beynon , Faten Alomar , Fiona R. Saunders , Raja Ebsim , Benjamin G. Faber , Mijin Jung , Jennifer S. Gregory , Claudia Lindner , Simon G.F. Abram , Richard M. Aspden , Nicholas C. Harvey , Timothy Cootes , Jonathan H. Tobias

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引用次数: 0

摘要

目的下肢排列可诱发或加重膝关节骨关节炎的症状。为了检查这种和其他关节形状变化的作用，我们进行了一项横断面研究，调查膝关节骨性关节炎（rKOA）和膝关节形状在英国生物银行（UKB）双能x射线吸收仪（DXA）图像中的关系。方法采用logistic回归分析前10种膝关节形状模式（KSMs）与rKOA等级之间的关系，并对年龄、性别、身高、体重和种族进行调整。另一个模型包括调整髋关节-膝关节-踝关节（HKA）角度，从全身DXA扫描得出，以反映膝关节对齐。合成图说明了与每个rKOA等级相关的膝盖形状特征。结果共纳入19053例（平均63.7岁，男性48%），其中rKOA等级分别为0、1、2、3-4级的占80.7%、14.6%、3.6%、1.2%。在混杂因素调整分析中，几个ksm与rKOA相关，分数越高，关系越强。这些关联通过调整HKA而减弱。正如预期的那样，复合形状模型显示较高的rKOA等级与较大的内翻错位相关。在HKA调整后，复合形状模型显示出较少的内翻对准，而其他形状差异，如胫骨近端干骺端改变和外侧髌骨移位，出现在更高级别的rKOA中。结论关节形状和dxa衍生的rKOA分级之间的横断面分析显示出与内翻错位的预期关系，在调整HKA后，这种关系减弱。其他形状的差异，特别是在更高等级的rKOA中，独立于排列而出现，值得进一步研究。

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Use of dual-energy X-ray absorptiometry to evaluate variation in bone shape and alignment associated with radiographic knee osteoarthritis: Findings from a study of 19,053 individuals in UK Biobank

Objective

Lower limb alignment may predispose to, or exacerbate, symptoms of knee osteoarthritis. To examine the role of this and other joint shape variation, we conducted a cross-sectional study investigating relationships between radiographic knee osteoarthritis (rKOA) and knee shape in dual-energy X-ray absorptiometry (DXA) images from UK Biobank (UKB).

Methods

Associations between the first ten knee shape modes (KSMs), derived from statistical shape modelling, and rKOA grade were analysed using logistic regression, adjusting for age, sex, height, weight, and ethnicity. An additional model included adjustment for hip-knee-ankle (HKA) angle, derived from total body DXA scans, to reflect knee alignment. Composite figures illustrate knee shape characteristics associated with each rKOA grade.

Results

19,053 individuals were included (mean 63.7 years, 48 % males), of whom 80.7 %, 14.6 %, 3.6 % and 1.2 % had rKOA grades 0, 1, 2 and 3–4, respectively. Several KSMs were associated with rKOA in confounder-adjusted analyses, with higher grades showing stronger relationships. These associations were attenuated by adjustment for HKA. As expected, composite shape models revealed that higher rKOA grades were associated with greater varus malalignment. After HKA adjustment, composite shape models showed less varus alignment, with other shape differences, such as altered proximal tibial metaphysis and lateral patella displacement, emerging in higher-grade rKOA.

Conclusions

Our cross-sectional analyses between joint shape and DXA-derived rKOA grade showed expected relationships with varus malalignment, which were attenuated after adjusting for HKA. Other shape differences, particularly in higher-grade rKOA, emerged independently of alignment, warranting further investigation.

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来源期刊

Osteoarthritis and cartilage open Orthopedics, Sports Medicine and Rehabilitation

CiteScore

3.30

自引率

0.00%

发文量