Maria Concetta Tenuta , Brigitte Deguin , Monica Rosa Loizzo , Fedora Grande , Matteo Brindisi , Maria Antonietta Occhiuzzi , Annabelle Dugay , Marco Bonesi , Giuseppe Antonio Malfa , Rosa Tundis
{"title":"探索作为生物活性化合物来源的副产物:血枝茱萸和山茱萸叶提取物和组分的LC-ESI-QTOF-MS分析和生物活性评估","authors":"Maria Concetta Tenuta , Brigitte Deguin , Monica Rosa Loizzo , Fedora Grande , Matteo Brindisi , Maria Antonietta Occhiuzzi , Annabelle Dugay , Marco Bonesi , Giuseppe Antonio Malfa , Rosa Tundis","doi":"10.1016/j.jff.2025.107002","DOIUrl":null,"url":null,"abstract":"<div><div>The increasing incidence of chronic diseases, interest in bioactive compounds from agro-industrial by-products is increasing. This study explored the chemical profile and bioactivities of <em>Cornus mas</em> and <em>Cornus sanguinea</em> leaf extracts obtained through various extraction methods, especially focusing on the lesser-known <em>C. sanguinea</em>. The study assessed their anti-inflammatory properties (inhibition of NF-κB, nitric oxide reduction), antioxidant activity, and hypoglycaemic effects (inhibition of α-amylase and α-glucosidase). LC-ESI-QTOF-MS analysis identified phenolic acids, iridoids, and flavonoids as key constituents. Hydroalcoholic maceration of dried <em>C. mas</em> and ethanol maceration of fresh <em>C. sanguinea</em> were fractionated using XAD-16 resin. Bioactivity was tested on fractions and on three key compounds: sweroside, cornuside, and ellagic acid. Sweroside and cornuside inhibited highly NO production. Moreover, sweroside exhibited a notable α-glucosidase inhibition. These findings highlight the potential benefits of <em>Cornus</em> leaves, providing a basis to develop <em>Cornus</em>-based products for the prevention or treatments for type 2 diabetes and inflammation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107002"},"PeriodicalIF":4.0000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring by-products as sources of bioactive compounds: LC-ESI-QTOF-MS profiling and bioactivity assessment of blood twig dogwood and cornelian cherry leaf extracts and fractions\",\"authors\":\"Maria Concetta Tenuta , Brigitte Deguin , Monica Rosa Loizzo , Fedora Grande , Matteo Brindisi , Maria Antonietta Occhiuzzi , Annabelle Dugay , Marco Bonesi , Giuseppe Antonio Malfa , Rosa Tundis\",\"doi\":\"10.1016/j.jff.2025.107002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The increasing incidence of chronic diseases, interest in bioactive compounds from agro-industrial by-products is increasing. This study explored the chemical profile and bioactivities of <em>Cornus mas</em> and <em>Cornus sanguinea</em> leaf extracts obtained through various extraction methods, especially focusing on the lesser-known <em>C. sanguinea</em>. The study assessed their anti-inflammatory properties (inhibition of NF-κB, nitric oxide reduction), antioxidant activity, and hypoglycaemic effects (inhibition of α-amylase and α-glucosidase). LC-ESI-QTOF-MS analysis identified phenolic acids, iridoids, and flavonoids as key constituents. Hydroalcoholic maceration of dried <em>C. mas</em> and ethanol maceration of fresh <em>C. sanguinea</em> were fractionated using XAD-16 resin. Bioactivity was tested on fractions and on three key compounds: sweroside, cornuside, and ellagic acid. Sweroside and cornuside inhibited highly NO production. Moreover, sweroside exhibited a notable α-glucosidase inhibition. These findings highlight the potential benefits of <em>Cornus</em> leaves, providing a basis to develop <em>Cornus</em>-based products for the prevention or treatments for type 2 diabetes and inflammation.</div></div>\",\"PeriodicalId\":360,\"journal\":{\"name\":\"Journal of Functional Foods\",\"volume\":\"133 \",\"pages\":\"Article 107002\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Functional Foods\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1756464625003445\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Functional Foods","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1756464625003445","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Exploring by-products as sources of bioactive compounds: LC-ESI-QTOF-MS profiling and bioactivity assessment of blood twig dogwood and cornelian cherry leaf extracts and fractions
The increasing incidence of chronic diseases, interest in bioactive compounds from agro-industrial by-products is increasing. This study explored the chemical profile and bioactivities of Cornus mas and Cornus sanguinea leaf extracts obtained through various extraction methods, especially focusing on the lesser-known C. sanguinea. The study assessed their anti-inflammatory properties (inhibition of NF-κB, nitric oxide reduction), antioxidant activity, and hypoglycaemic effects (inhibition of α-amylase and α-glucosidase). LC-ESI-QTOF-MS analysis identified phenolic acids, iridoids, and flavonoids as key constituents. Hydroalcoholic maceration of dried C. mas and ethanol maceration of fresh C. sanguinea were fractionated using XAD-16 resin. Bioactivity was tested on fractions and on three key compounds: sweroside, cornuside, and ellagic acid. Sweroside and cornuside inhibited highly NO production. Moreover, sweroside exhibited a notable α-glucosidase inhibition. These findings highlight the potential benefits of Cornus leaves, providing a basis to develop Cornus-based products for the prevention or treatments for type 2 diabetes and inflammation.
期刊介绍:
Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies.
The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients.
The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.