一种新颖的集成软件解决方案，为hla敏感患者提供兼容的血小板

IF 2.2 4区医学 Q3 IMMUNOLOGY

Human Immunology Pub Date : 2025-09-01 DOI:10.1016/j.humimm.2025.111570

Ryan Morlen , Kevin Grieger , Collin Brack , Krystal Bullard , Yan Zheng , Paula Y. Arnold

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引用次数: 0

摘要

对敏感患者的输血支持是血液中心和HLA实验室的重要功能。然而，获得广泛可用的软件来促进患者与兼容的供体单位的匹配是有限的。我们开发了供应商支持的集成软件，该软件与实验室信息系统接口，从我们的血小板供体注册表中获取分型数据，检索患者HLA分型和不可接受的抗体特异性。该应用程序过滤抗原阴性献血者，并使用结合HLA匹配、献血者纯合性和不匹配抗原的交叉反应组比较的算法对他们进行排名，并为血液中心生成可定制的献血者排名报告。低，中，高抗体反应可以过滤，以更好地支持高度敏感的患者。实现供应商支持的软件可确保持续的维护、支持和不断发展的血小板匹配协议的更新机会。这种可定制的解决方案减少了转录错误，简化了数据检索，允许为患者提供及时有效的输血支持。

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A novel and integrated software solution for providing compatible platelets to HLA-sensitized patients

Transfusion support for sensitized patients is an important function of blood centers and HLA laboratories. However, access to widely available software to facilitate matching patients with compatible donor units is limited. We developed vendor-supported and integrated software that interfaces with the laboratory informatics system, sourcing typing data from our platelet donor registry and retrieving patient HLA typing and unacceptable antibody specificities. The application filters antigen-negative donors and ranks them using an algorithm that incorporates HLA match, donor homozygosity, and cross-reactive group comparison for mismatched antigens, and generates a customizable report of ranked donors for the blood center. Low, moderate, and high antibody reactivities can be filtered to better support highly sensitized patients. Implementing vendor-supported software ensures continued maintenance, support, and the opportunity for updates with evolving platelet matching protocols. This customizable solution reduces transcription errors and streamlines data retrieval, allowing provision of timely and efficient transfusion support for patients.

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来源期刊

Human Immunology 医学-免疫学

CiteScore

5.40

自引率

7.40%

发文量

107

审稿时长

12 days

期刊介绍： The journal''s scope includes understanding the genetic and functional mechanisms that distinguish human individuals in their immune responses to allografts, pregnancy, infections or vaccines as well as the immune responses that lead to autoimmunity, allergy or drug hypersensitivity. It also includes examining the distribution of the genes controlling these responses in populations. Research areas include: Studies of the genetics, genomics, polymorphism, evolution, and population distribution of immune-related genes Studies of the expression, structure and function of the products of immune-related genes Immunogenetics of susceptibility to infectious and autoimmune disease, and allergy The role of the immune-related genes in hematopoietic stem cell, solid organ, and vascularized composite allograft transplant Histocompatibility studies including alloantibodies, epitope definition, and T cell alloreactivity Studies of immunologic tolerance and pregnancy T cell, B cell, NK and regulatory cell functions, particularly related to subjects within the journal''s scope Pharmacogenomics and vaccine development in the context of immune-related genes Human Immunology considers immune-related genes to include those encoding classical and non-classical HLA, KIR, MIC, minor histocompatibility antigens (mHAg), immunoglobulins, TCR, BCR, proteins involved in antigen processing and presentation, complement, Fc receptors, chemokines and cytokines. Other immune-related genes may be considered. Human Immunology is also interested in bioinformatics of immune-related genes and organizational topics impacting laboratory processes, organ allocation, clinical strategies, and registries related to autoimmunity and transplantation.