对峙：干细胞疗法对抗免疫系统

IF 20.4 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-09-04 DOI:10.1016/j.stem.2025.08.009

Roberto Castro-Gutierrez, Qizhi Tang

{"title":"对峙：干细胞疗法对抗免疫系统","authors":"Roberto Castro-Gutierrez, Qizhi Tang","doi":"10.1016/j.stem.2025.08.009","DOIUrl":null,"url":null,"abstract":"As stem cell therapies make great strides in clinical trials, the challenge of immune rejection has come into a sharper focus. Several recent clinical reports provide insight into the challenges posed by HLA mismatch and immunosuppression. Immunological analyses accompanying recent cell therapy trials suggest strategies that may mitigate these risks.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"16 1","pages":""},"PeriodicalIF":20.4000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Face off: Stem cell therapy versus the immune system\",\"authors\":\"Roberto Castro-Gutierrez, Qizhi Tang\",\"doi\":\"10.1016/j.stem.2025.08.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"As stem cell therapies make great strides in clinical trials, the challenge of immune rejection has come into a sharper focus. Several recent clinical reports provide insight into the challenges posed by HLA mismatch and immunosuppression. Immunological analyses accompanying recent cell therapy trials suggest strategies that may mitigate these risks.\",\"PeriodicalId\":9665,\"journal\":{\"name\":\"Cell stem cell\",\"volume\":\"16 1\",\"pages\":\"\"},\"PeriodicalIF\":20.4000,\"publicationDate\":\"2025-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell stem cell\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.stem.2025.08.009\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL & TISSUE ENGINEERING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell stem cell","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.stem.2025.08.009","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL & TISSUE ENGINEERING","Score":null,"Total":0}

引用次数: 0

摘要

随着干细胞疗法在临床试验中取得巨大进展，免疫排斥的挑战已经成为一个更尖锐的焦点。最近的一些临床报告提供了对HLA错配和免疫抑制带来的挑战的见解。伴随最近细胞治疗试验的免疫学分析提出了可能减轻这些风险的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Face off: Stem cell therapy versus the immune system

As stem cell therapies make great strides in clinical trials, the challenge of immune rejection has come into a sharper focus. Several recent clinical reports provide insight into the challenges posed by HLA mismatch and immunosuppression. Immunological analyses accompanying recent cell therapy trials suggest strategies that may mitigate these risks.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.