{"title":"球囊肺动脉成形术对慢性血栓栓塞性肺动脉高压诊断的影响：来自命令VTE登记-2。","authors":"Tatsunori Noto, Nobutaka Ikeda, Yugo Yamashita, Takeshi Morimoto, Ryuki Chatani, Kazuhisa Kaneda, Yuji Nishimoto, Yohei Kobayashi, Satoshi Ikeda, Kitae Kim, Moriaki Inoko, Toru Takase, Shuhei Tsuji, Maki Oi, Takuma Takada, Kazunori Otsui, Jiro Sakamoto, Yoshito Ogihara, Takeshi Inoue, Shunsuke Usami, Po-Min Chen, Kiyonori Togi, Norimichi Koitabashi, Seiichi Hiramori, Kosuke Doi, Hiroshi Mabuchi, Yoshiaki Tsuyuki, Koichiro Murata, Kensuke Takabayashi, Hisato Nakai, Daisuke Sueta, Wataru Shioyama, Tomohiro Dohke, Takeshi Kimura, COMMAND VTE Registry-2 Investigators","doi":"10.1002/ccd.70130","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Chronic thromboembolic pulmonary hypertension (CTEPH) is the most serious long-term complication of acute pulmonary embolism (PE). Balloon pulmonary angioplasty (BPA) has been an effective treatment for improving the prognosis of CTEPH patients.</p>\n </section>\n \n <section>\n \n <h3> Aims</h3>\n \n <p>This study aimed to evaluate the impact of BPA at each institution on the rate of CTEPH diagnosis based on the observations suggesting that the emergence of effective treatments could draw attention to targeted diseases.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The COMMAND VTE Registry-2 is a multicenter, retrospective cohort study of 5197 patients diagnosed with venous thromboembolism (VTE) at 31 medical centers in Japan. The study included 2787 patients with acute PE, who were divided into the BPA-capable facility group (BPA centers) and the non-BPA-capable facility group (non-BPA centers). We investigated the difference in the rate of CTEPH diagnosis after acute PE between the two groups.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Among patients with acute PE, 723 patients (25.9%) and 2064 patients (74.1%) were diagnosed at BPA centers and non-BPA centers, respectively. There were 48 patients who were diagnosed with CTEPH, with a median follow-up period of 747 days. The cumulative 3-year incidence of CTEPH diagnosis was 5.0% in the BPA centers and 1.4% in the non-BPA centers (crude hazard ratio [HR]: 3.80; 95% CI: 2.15–6.72; <i>p</i> < 0.001).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The cumulative 3-year incidence of CTEPH diagnosis after acute PE was significantly greater in BPA centers than in non-BPA centers, which suggests the importance of appropriate awareness of CTEPH and BPA.</p>\n </section>\n </div>","PeriodicalId":9650,"journal":{"name":"Catheterization and Cardiovascular Interventions","volume":"106 4","pages":"2753-2762"},"PeriodicalIF":1.9000,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of the Balloon Pulmonary Angioplasty on the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension: From the COMMAND VTE Registry-2\",\"authors\":\"Tatsunori Noto, Nobutaka Ikeda, Yugo Yamashita, Takeshi Morimoto, Ryuki Chatani, Kazuhisa Kaneda, Yuji Nishimoto, Yohei Kobayashi, Satoshi Ikeda, Kitae Kim, Moriaki Inoko, Toru Takase, Shuhei Tsuji, Maki Oi, Takuma Takada, Kazunori Otsui, Jiro Sakamoto, Yoshito Ogihara, Takeshi Inoue, Shunsuke Usami, Po-Min Chen, Kiyonori Togi, Norimichi Koitabashi, Seiichi Hiramori, Kosuke Doi, Hiroshi Mabuchi, Yoshiaki Tsuyuki, Koichiro Murata, Kensuke Takabayashi, Hisato Nakai, Daisuke Sueta, Wataru Shioyama, Tomohiro Dohke, Takeshi Kimura, COMMAND VTE Registry-2 Investigators\",\"doi\":\"10.1002/ccd.70130\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Chronic thromboembolic pulmonary hypertension (CTEPH) is the most serious long-term complication of acute pulmonary embolism (PE). Balloon pulmonary angioplasty (BPA) has been an effective treatment for improving the prognosis of CTEPH patients.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Aims</h3>\\n \\n <p>This study aimed to evaluate the impact of BPA at each institution on the rate of CTEPH diagnosis based on the observations suggesting that the emergence of effective treatments could draw attention to targeted diseases.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>The COMMAND VTE Registry-2 is a multicenter, retrospective cohort study of 5197 patients diagnosed with venous thromboembolism (VTE) at 31 medical centers in Japan. The study included 2787 patients with acute PE, who were divided into the BPA-capable facility group (BPA centers) and the non-BPA-capable facility group (non-BPA centers). We investigated the difference in the rate of CTEPH diagnosis after acute PE between the two groups.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Among patients with acute PE, 723 patients (25.9%) and 2064 patients (74.1%) were diagnosed at BPA centers and non-BPA centers, respectively. There were 48 patients who were diagnosed with CTEPH, with a median follow-up period of 747 days. The cumulative 3-year incidence of CTEPH diagnosis was 5.0% in the BPA centers and 1.4% in the non-BPA centers (crude hazard ratio [HR]: 3.80; 95% CI: 2.15–6.72; <i>p</i> < 0.001).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>The cumulative 3-year incidence of CTEPH diagnosis after acute PE was significantly greater in BPA centers than in non-BPA centers, which suggests the importance of appropriate awareness of CTEPH and BPA.</p>\\n </section>\\n </div>\",\"PeriodicalId\":9650,\"journal\":{\"name\":\"Catheterization and Cardiovascular Interventions\",\"volume\":\"106 4\",\"pages\":\"2753-2762\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Catheterization and Cardiovascular Interventions\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ccd.70130\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Catheterization and Cardiovascular Interventions","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ccd.70130","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Impact of the Balloon Pulmonary Angioplasty on the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension: From the COMMAND VTE Registry-2
Background
Chronic thromboembolic pulmonary hypertension (CTEPH) is the most serious long-term complication of acute pulmonary embolism (PE). Balloon pulmonary angioplasty (BPA) has been an effective treatment for improving the prognosis of CTEPH patients.
Aims
This study aimed to evaluate the impact of BPA at each institution on the rate of CTEPH diagnosis based on the observations suggesting that the emergence of effective treatments could draw attention to targeted diseases.
Methods
The COMMAND VTE Registry-2 is a multicenter, retrospective cohort study of 5197 patients diagnosed with venous thromboembolism (VTE) at 31 medical centers in Japan. The study included 2787 patients with acute PE, who were divided into the BPA-capable facility group (BPA centers) and the non-BPA-capable facility group (non-BPA centers). We investigated the difference in the rate of CTEPH diagnosis after acute PE between the two groups.
Results
Among patients with acute PE, 723 patients (25.9%) and 2064 patients (74.1%) were diagnosed at BPA centers and non-BPA centers, respectively. There were 48 patients who were diagnosed with CTEPH, with a median follow-up period of 747 days. The cumulative 3-year incidence of CTEPH diagnosis was 5.0% in the BPA centers and 1.4% in the non-BPA centers (crude hazard ratio [HR]: 3.80; 95% CI: 2.15–6.72; p < 0.001).
Conclusion
The cumulative 3-year incidence of CTEPH diagnosis after acute PE was significantly greater in BPA centers than in non-BPA centers, which suggests the importance of appropriate awareness of CTEPH and BPA.
期刊介绍：
Catheterization and Cardiovascular Interventions is an international journal covering the broad field of cardiovascular diseases. Subject material includes basic and clinical information that is derived from or related to invasive and interventional coronary or peripheral vascular techniques. The journal focuses on material that will be of immediate practical value to physicians providing patient care in the clinical laboratory setting. To accomplish this, the journal publishes Preliminary Reports and Work In Progress articles that complement the traditional Original Studies, Case Reports, and Comprehensive Reviews. Perspective and insight concerning controversial subjects and evolving technologies are provided regularly through Editorial Commentaries furnished by members of the Editorial Board and other experts. Articles are subject to double-blind peer review and complete editorial evaluation prior to any decision regarding acceptability.
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