离束剂量法对头颈癌和CIED患者危险组分类的研究。

IF 4.2
Larissa Blümlein, Oliver Kölbl, Ralf Ringler, Barbara Dobler
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引用次数: 0

摘要

现行指南[1]根据心脏植入式电子装置(CIED)的最大剂量(Dmax)将患者分为危险组,以避免发生故障。如果CIED位于辐射场之外,治疗计划系统(TPS)的剂量计算不够准确,无法进行安全分类。在某些情况下,在治疗期间将磁铁放置在CIED上以使抗心动过速(ATA)治疗失活。然而,磁体不包括在治疗计划过程中,这导致CIED剂量测定的进一步不确定性。本研究的目的是研究磁体对CIED剂量的影响,并检查磁体纳入TPS是否可以更准确地预测剂量,从而对患者进行安全分类。计算了15例鼻咽癌或食管癌患者使用和不使用磁体的治疗方案,并将其转移到具有集成CIED的假体。用热释光探测器(TLDs)和放射致色膜对治疗方案进行验证。我们的研究显示,TPS对CIED的剂量平均高估了0.4 Gy(20%)。放疗期间用于ATA失活的磁体对CIED的剂量平均略有增加0.1 Gy。对于食管癌或口腔癌/鼻咽癌患者的体积调制电弧治疗(VMAT)照射,在大多数情况下,磁铁的放置对CIED剂量没有临床相关的影响。在TPS中加入磁体对计算的CIED剂量没有影响,也没有改变危险组的分类。尽管剂量计算存在不确定性,但TPS摩纳哥的风险分类在97%的病例中是安全的,即使使用磁铁来灭活ATA并且不包括在治疗计划过程中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Off beam dosimetry for risk group classification for patients with head and neck cancer and CIED.

Current guidelines [1] classify patients with cardiac implantable electronic devices (CIED) into risk groups based on the maximal CIED dose (Dmax) to avoid malfunctions. If a CIED is located outside the radiation field, dose calculation by treatment planning systems (TPS) is not sufficiently accurate for safe classification. In certain cases, a magnet is placed on the CIED for deactivation of antitachyarrhythmia (ATA) therapy during treatment. The magnet is, however, not included in the treatment planning process, which leads to further uncertainty in the dose determination at the CIED. The aim of the study was to investigate the influence of the magnet on CIED dose and to examine if the inclusion of the magnet in the TPS allows a more accurate dose prediction for safe classification of the patients. Treatment plans with and without the magnet were calculated for 15 patients with naso-/orpharyngeal or esophageal carcinoma and transferred to a phantom with integrated CIED. Treatment plan verification was performed with thermoluminescence detectors (TLDs) and radiochromic films. Our study showed an overestimation of the dose in the CIED by the TPS by 0.4 Gy (20 %) on average. The magnet used for ATA deactivation during radiotherapy increased the dose to the CIED slightly by 0.1 Gy on average. For Volumetric Modulated Arc Therapy (VMAT) irradiations of patients with esophageal or oro-/nasopharyngeal carcinoma, placement of the magnet had no clinically relevant impact on the CIED dose in most of the cases. The inclusion of the magnet in the TPS had no influence on calculated CIED dose and did not change the classification into risk groups. Despite uncertainties in the dose calculation, risk classification by the TPS Monaco was safe in 97 % of the cases, even if a magnet was used for ATA deactivation and not included in the treatment planning process.

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