BMI,睡眠结构和葡萄糖代谢:来自Baependi心脏研究的见解。

IF 4.7 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Obesity Pub Date : 2025-07-30 DOI:10.1002/oby.24359
Carolina Mendes Pessoa, Tâmara P. Taporoski, Felipe Beijamini, Shaina J. Alexandria, Jose E. Krieger, Malcolm von Schantz, Alexandre C. Pereira, Kristen L. Knutson
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引用次数: 0

摘要

目的:探讨(1)无睡眠呼吸暂停时睡眠结构是否与BMI组相关,(2)BMI组是否改变了睡眠结构与葡萄糖代谢标志物之间的关系。方法:Baependi心脏研究(BHS)是一项基于家庭的成人观察性研究,使用家庭多导睡眠图(PSG)评估睡眠,收集人体测量和空腹血测量。BMI分为:18.5 - 2。患有中度重度睡眠呼吸暂停并正在服用糖尿病相关药物的人被排除在外。研究了横断面相关性(n = 1014)。结果:BMI≥30 kg/m2组快速眼动睡眠时间较短(-7.8 min, p = 0.003), BMI 25 ~ 2组和≥30 kg/m2组呼吸暂停低通气指数高于BMI 18.5 ~ 2组(分别比BMI 18.5 ~ 2组高0.8和1.4次/ h, p = 0.002); WASO增加10 min与空腹血糖升高约1%相关(p = 0.002)。结论:在排除中重度睡眠呼吸暂停的参与者后,BMI组之间的非快速眼动睡眠没有差异,快速眼动睡眠只有很小的差异,这表明BMI不会严重损害睡眠,除非存在睡眠呼吸暂停。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

BMI, Sleep Architecture, and Glucose Metabolism: Insights From the Baependi Heart Study

BMI, Sleep Architecture, and Glucose Metabolism: Insights From the Baependi Heart Study

Objective

To examine whether (1) sleep architecture is associated with BMI groups in the absence of sleep apnea and (2) BMI group modified associations between sleep architecture and markers of glucose metabolism.

Methods

The Baependi Heart Study (BHS) is a family-based observational study of adults that assessed sleep using at-home polysomnography (PSG) and collected anthropometric and fasting blood measures. BMI was classified into: 18.5 to < 25, 25 to < 30, and ≥ 30 kg/m2. People with moderate–severe sleep apnea and taking diabetes-related medication were excluded. Cross-sectional associations were examined (n = 1014).

Results

Individuals with BMI ≥ 30 kg/m2 had less REM sleep (−7.8 min, p = 0.003) and the groups with BMI 25 to < 30 kg/m2 and ≥ 30 kg/m2 had higher apnea-hypopnea index than individuals with BMI 18.5 to < 25 kg/m2 (by 0.8 and 1.4 events per hour, respectively, p < =0.002). Wake after sleep onset (WASO) was associated with higher fasting glucose levels in participants with BMI ≥ 30 kg/m2 only; 10 min more WASO was associated with ~1% higher fasting glucose (p = 0.002).

Conclusions

After exclusion of participants with moderate–severe sleep apnea, there was no difference in non-REM sleep and only a small difference in REM sleep between BMI groups, suggesting that BMI does not substantially impair sleep unless sleep apnea is present.

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来源期刊
Obesity
Obesity 医学-内分泌学与代谢
CiteScore
11.70
自引率
1.40%
发文量
261
审稿时长
2-4 weeks
期刊介绍: Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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