有氧和抗阻联合运动对中老年血糖和血脂异常男性动脉僵硬的影响：一项为期12周的干预研究

IF 4.3

Experimental gerontology Pub Date : 2025-08-31 DOI:10.1016/j.exger.2025.112879

Yifan Feng , Boming Li , Peng Lu , Boli Cheng , Zhengxuan Bao , Liqiang Su , Dayong Qiu , Yunqing Liu , Fanghui Li

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引用次数: 0

摘要

背景：本研究的目的是评估12周有氧和阻力联合运动计划对血糖和血脂异常患者血管功能的影响。方法：参与者年龄在45-69岁 岁，身体质量指数（BMI） 2且血糖或血脂水平异常。所有参与者每周进行两次有氧训练和一次阻力训练，持续12 周。结果：有氧运动结合抗阻训练干预12周后，血糖、糖化血红蛋白、糖化血红蛋白（HbA1c）、低密度脂蛋白（LDL）和舒张压在血糖异常和血脂异常个体中显著降低。右心踝血管指数（CAVI）和双侧踝肱血管指数（ABI）明显增强（p ）。结论：运动方案显著改善了糖脂代谢异常患者的动脉僵硬度，同时减轻了梗阻。ABI改善的程度与HbA1c的降低相关（p = 0.049），表明运动对血管功能有积极影响，可能受血糖水平调节。临床意义：在运动过程中补充降低血糖的措施可能有益于血管功能。试验报名：IRB号：NNU202310007。

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Effects of combined aerobic and resistance exercise on arterial stiffness in middle-aged and older men with dysglycemia and dyslipidemia: A 12-week intervention study

Background

The aim of this study was to evaluate the effects of 12-week combined aerobic and resistance exercise program on vascular function in individuals with dysglycemia and dyslipidemia.

Methods

Participants aged 45–69 years with a Body Mass Index (BMI) < 35 kg/m² and abnormal blood glucose or lipid levels were included. All participants performed two aerobic training sessions and one resistance training session per week for 12 weeks.

Results

After a 12-week intervention of aerobic exercise combined with resistance training, significant reductions in weight, BMI, blood glucose, Glycosylated Hemoglobin, Type A1C (HbA1c), low-density lipoprotein (LDL), and diastolic blood pressure in individuals with dysglycemia and dyslipidemia. The right cardio-ankle vascular index (CAVI) and the bilateral ankle-brachial index (ABI) showed highly significant enhancement (p < 0.001). When grouping based on pre-exercise blood glucose levels, only the impaired fasting glucose group exhibited significant improvement in right CAVI (p = 0.045) and left ABI (p = 0.039). Comparison between the groups revealed that the ABI after exercise was significantly higher in the normoglycaemic individuals than in the other two groups (p = 0.029). Both blood glucose levels and exercise significantly affected left ABI changes (p = 0.017), but no interaction was found (p = 0.081). When grouping was based on pre-exercise lipid levels, analysis showed no significant CAVI changes, but bilateral ABIs improved significantly. Furthermore, a notable association between HbA1c changes and right ABI (p = 0.049).

Conclusions

The exercise regimen significantly improved arterial stiffness, while reducing obstruction in those with abnormal glucose and lipid metabolism. The extent of ABI improvement correlated with reductions in HbA1c (p = 0.049), suggesting that exercise positively influences vascular function, potentially modulated by glucose levels.