Assessing Large Multimodal Models for One-Shot Learning and Interpretability in Biomedical Image Classification.

Image classification plays a pivotal role in analyzing biomedical images, serving as a cornerstone for both biological research and clinical diagnostics. It is demonstrated that large multimodal models (LMMs), like GPT-4, excel in one-shot learning, generalization, interpretability, and text-driven image classification across diverse biomedical tasks. These tasks include the classification of tissues, cell types, cellular states, and disease status. LMMs stand out from traditional single-modal classification approaches, which often require large training datasets and offer limited interpretability.