{"title":"阻断SKI-1挽救血脑屏障，改善中风恢复。","authors":"Ken Arai, Masafumi Ihara","doi":"10.1038/s44161-025-00683-5","DOIUrl":null,"url":null,"abstract":"The blood–brain barrier is an important therapeutic target in the development of drugs to treat stroke. A recent study finds that inhibiting SKI-1 protects blood–brain barrier integrity and improves neurological recovery in mouse and rabbit models of stroke.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 9","pages":"1040-1042"},"PeriodicalIF":10.8000,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Blocking SKI-1 to rescue the blood–brain barrier and improve stroke recovery\",\"authors\":\"Ken Arai, Masafumi Ihara\",\"doi\":\"10.1038/s44161-025-00683-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The blood–brain barrier is an important therapeutic target in the development of drugs to treat stroke. A recent study finds that inhibiting SKI-1 protects blood–brain barrier integrity and improves neurological recovery in mouse and rabbit models of stroke.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"4 9\",\"pages\":\"1040-1042\"},\"PeriodicalIF\":10.8000,\"publicationDate\":\"2025-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-025-00683-5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-025-00683-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Blocking SKI-1 to rescue the blood–brain barrier and improve stroke recovery
The blood–brain barrier is an important therapeutic target in the development of drugs to treat stroke. A recent study finds that inhibiting SKI-1 protects blood–brain barrier integrity and improves neurological recovery in mouse and rabbit models of stroke.
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