{"title":"层粘连蛋白在秀丽隐杆线虫腹侧和背侧神经索纵轴突束周围的基底膜上均匀表达。","authors":"Harald Hutter","doi":"10.17912/micropub.biology.001766","DOIUrl":null,"url":null,"abstract":"<p><p>Laminin is a core basement membrane (BM) component. Mutations in laminin subunits cause a variety of defects including axon navigation defects. We examined the localization of the laminin subunits LAM-3 (laminin αA), EPI-1 (laminin αB) and LAM-2 (laminin γ) in basement membranes surrounding the ventral nerve cord (VNC) and the dorsal nerve cord (DNC) in <i>C. elegans</i> . We found that EPI-1 and LAM-2 are uniformly distributed, which suggests that laminins might provide an adhesive substrate for axons but not a directional cue for the positioning of VNC and DNC axon tracts.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381658/pdf/","citationCount":"0","resultStr":"{\"title\":\"Laminin is uniformly expressed in basement membranes surrounding longitudinal axon tracts in the ventral and dorsal nerve cords in <i>C. elegans</i>.\",\"authors\":\"Harald Hutter\",\"doi\":\"10.17912/micropub.biology.001766\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Laminin is a core basement membrane (BM) component. Mutations in laminin subunits cause a variety of defects including axon navigation defects. We examined the localization of the laminin subunits LAM-3 (laminin αA), EPI-1 (laminin αB) and LAM-2 (laminin γ) in basement membranes surrounding the ventral nerve cord (VNC) and the dorsal nerve cord (DNC) in <i>C. elegans</i> . We found that EPI-1 and LAM-2 are uniformly distributed, which suggests that laminins might provide an adhesive substrate for axons but not a directional cue for the positioning of VNC and DNC axon tracts.</p>\",\"PeriodicalId\":74192,\"journal\":{\"name\":\"microPublication biology\",\"volume\":\"2025 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381658/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"microPublication biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17912/micropub.biology.001766\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"microPublication biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17912/micropub.biology.001766","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Laminin is uniformly expressed in basement membranes surrounding longitudinal axon tracts in the ventral and dorsal nerve cords in C. elegans.
Laminin is a core basement membrane (BM) component. Mutations in laminin subunits cause a variety of defects including axon navigation defects. We examined the localization of the laminin subunits LAM-3 (laminin αA), EPI-1 (laminin αB) and LAM-2 (laminin γ) in basement membranes surrounding the ventral nerve cord (VNC) and the dorsal nerve cord (DNC) in C. elegans . We found that EPI-1 and LAM-2 are uniformly distributed, which suggests that laminins might provide an adhesive substrate for axons but not a directional cue for the positioning of VNC and DNC axon tracts.
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