Manal Al Dow, Charles Colas, Blandine Secco, Alona Kolnohuz, Nolwenn Samson, Audrey Poirier, Romain Villot, Laurence Belley, Bochra Chadel, Laura Tribouillard, Alyson Dufour, Mathilde Mouchiroud, Yves Gélinas, Mathieu C Morissette, Mathieu Laplante
{"title":"PITX2在高度成脂的棕色前脂肪细胞中富集。","authors":"Manal Al Dow, Charles Colas, Blandine Secco, Alona Kolnohuz, Nolwenn Samson, Audrey Poirier, Romain Villot, Laurence Belley, Bochra Chadel, Laura Tribouillard, Alyson Dufour, Mathilde Mouchiroud, Yves Gélinas, Mathieu C Morissette, Mathieu Laplante","doi":"10.17912/micropub.biology.001570","DOIUrl":null,"url":null,"abstract":"<p><p>Brown adipose tissue (BAT) serves as a key heat-producing organ required to maintain body temperature and homeothermy in mammals. BAT recruitment and activation deeply impacts metabolic homeostasis in both mice and humans. Despite recent advances, the nature of the factors that functionally characterize brown adipose precursors are still incompletely characterized. Here, we provide a comprehensive transcriptomic analysis of brown preadipocyte cell lines with low or high adipogenic potential. Using this resource, we report the identification of paired-like homeodomain 2 (PITX2) as a transcription factor highly enriched in committed brown preadipocytes.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364533/pdf/","citationCount":"0","resultStr":"{\"title\":\"PITX2 is enriched in highly adipogenic brown preadipocytes.\",\"authors\":\"Manal Al Dow, Charles Colas, Blandine Secco, Alona Kolnohuz, Nolwenn Samson, Audrey Poirier, Romain Villot, Laurence Belley, Bochra Chadel, Laura Tribouillard, Alyson Dufour, Mathilde Mouchiroud, Yves Gélinas, Mathieu C Morissette, Mathieu Laplante\",\"doi\":\"10.17912/micropub.biology.001570\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Brown adipose tissue (BAT) serves as a key heat-producing organ required to maintain body temperature and homeothermy in mammals. BAT recruitment and activation deeply impacts metabolic homeostasis in both mice and humans. Despite recent advances, the nature of the factors that functionally characterize brown adipose precursors are still incompletely characterized. Here, we provide a comprehensive transcriptomic analysis of brown preadipocyte cell lines with low or high adipogenic potential. Using this resource, we report the identification of paired-like homeodomain 2 (PITX2) as a transcription factor highly enriched in committed brown preadipocytes.</p>\",\"PeriodicalId\":74192,\"journal\":{\"name\":\"microPublication biology\",\"volume\":\"2025 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364533/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"microPublication biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17912/micropub.biology.001570\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"microPublication biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17912/micropub.biology.001570","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
PITX2 is enriched in highly adipogenic brown preadipocytes.
Brown adipose tissue (BAT) serves as a key heat-producing organ required to maintain body temperature and homeothermy in mammals. BAT recruitment and activation deeply impacts metabolic homeostasis in both mice and humans. Despite recent advances, the nature of the factors that functionally characterize brown adipose precursors are still incompletely characterized. Here, we provide a comprehensive transcriptomic analysis of brown preadipocyte cell lines with low or high adipogenic potential. Using this resource, we report the identification of paired-like homeodomain 2 (PITX2) as a transcription factor highly enriched in committed brown preadipocytes.
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