用玻璃瓶代替无聚氯乙烯、dehp采血袋在氧-臭氧治疗中产生溶血。

Marianno Franzini, Salvatore Chirumbolo, Luigi Valdenassi
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引用次数: 0

摘要

本研究探讨了在氧-臭氧(o2 - o2 - 3 -MAHT)自体血液治疗中,使用玻璃瓶和不含dehp的PVC塑料袋进行自体血液采集的安全性影响。在玻璃容器中采集血液会增加溶血,特别是由于高剪切应力、表面不规则和真空采集相关的湍流,引起了人们的担忧。输血医学的历史数据已经证实,玻璃会导致更高的红细胞破裂率,这一发现通过本研究的数学模型和模拟得到了证实。血红蛋白的释放和后血红蛋白的形成都是促炎介质,对患者安全构成潜在风险。作者应用常微分方程(ode)来模拟溶血、生化稳定性和炎症反应,结果表明塑料袋能更好地保存红细胞完整性并降低炎症风险。泡沫形成、白蛋白吸附和氧合效果的对比数据进一步强化了塑料容器的优势。预测模型表明,使用玻璃会显著增加治疗失败和安全风险,特别是在臭氧剂量较高的情况下。该研究得出结论,无dehp塑料袋为O 2 -O 3 -MAHT提供了一种更可靠、更安全、更具有生物相容性的方法,并建议逐步淘汰玻璃瓶,以尽量减少溶血现象,并确保医疗臭氧程序的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Haemolysis Generated with the Use of Glass Bottles Instead of PVC, DEHP-Free Blood Collection Bags in the Oxygen-Ozone Therapy.

This study investigates the safety implications of using glass bottles versus PVC, DEHP-free plastic bags for autologous blood collection in major autohaemotherapy with oxygen-ozone (O 2 -O 3 -MAHT). Concerns have arisen regarding increased haemolysis when blood is collected in glass containers, particularly due to high shear stress, surface irregularities and turbulence associated with vacuum-based collection. Historical data from transfusion medicine already established that glass induces higher red blood cell (RBC) rupture rates, a finding confirmed through mathematical modelling and simulations in this study. The release of haemoglobin and formation of meta-haemoglobin, both pro-inflammatory mediators, pose potential risks to patient safety. The authors applied ordinary differential equations (ODEs) to model haemolysis, biochemical stability and inflammatory responses, revealing that plastic bags offer superior preservation of RBC integrity and reduce inflammation risks. Comparative data on foam formation, albumin adsorption and oxygenation efficacy further reinforce the advantage of plastic containers. Forecast modelling suggests that treatment failure and safety risks increase significantly with glass use, particularly at higher ozone doses. The study concludes that DEHP-free plastic bags provide a more reliable, safe and biocompatible method for O 2 -O 3 -MAHT and recommends phasing out glass bottles to minimize haemolysis and ensure the therapeutic efficacy of medical ozone procedures.

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