{"title":"不对称多局灶神经系统症状与狗的贫血,嗜碱性低肾上腺皮质症和严重低血糖。","authors":"Cameron A. D. Morris, Rebekah E. Donaldson","doi":"10.1111/vec.70019","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>To describe the clinical presentation of a dog with eunatremic, eukalemic hypoadrenocorticism (EEH) with multifocal, asymmetrical neurological signs.</p>\n </section>\n \n <section>\n \n <h3> Case Summary</h3>\n \n <p>A 7-year-old neutered male miniature Poodle presented for collapse, vomiting, and acute onset of neurological signs. The dog was obtunded and nonambulatory, with a right-sided head tilt and turn with rotary nystagmus. No seizure activity was observed by the owner. The patient was in hypovolemic shock. Hypoglycemia, mild azotemia, and metabolic acidosis characterized by hyperlactatemia were identified. Magnetic resonance imaging of the brain and CSF analysis performed within 24 h of presentation were unremarkable. ACTH stimulation testing confirmed hypoadrenocorticism. Neurological signs failed to significantly improve despite systemic stabilization, glucose supplementation, and dexamethasone administration until approximately 48 h following admission. A mild proprioceptive ataxia was present at discharge approximately 84 h following admission and had resolved by the time of initial recheck 7 days following discharge.</p>\n </section>\n \n <section>\n \n <h3> New Information Provided</h3>\n \n <p>EEH can cause neurological signs with forebrain localization that are typically symmetrical due to the global nature of the injury. To the authors’ knowledge, this is the first report of a dog with EEH presenting with severe, asymmetric, and multifocal neurological signs.</p>\n </section>\n </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"35 4","pages":"455-460"},"PeriodicalIF":1.2000,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Asymmetric Multifocal Neurological Signs in a Dog With Eunatremic, Eukalemic Hypoadrenocorticism With Severe Hypoglycemia\",\"authors\":\"Cameron A. D. Morris, Rebekah E. Donaldson\",\"doi\":\"10.1111/vec.70019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>To describe the clinical presentation of a dog with eunatremic, eukalemic hypoadrenocorticism (EEH) with multifocal, asymmetrical neurological signs.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Case Summary</h3>\\n \\n <p>A 7-year-old neutered male miniature Poodle presented for collapse, vomiting, and acute onset of neurological signs. The dog was obtunded and nonambulatory, with a right-sided head tilt and turn with rotary nystagmus. No seizure activity was observed by the owner. The patient was in hypovolemic shock. Hypoglycemia, mild azotemia, and metabolic acidosis characterized by hyperlactatemia were identified. Magnetic resonance imaging of the brain and CSF analysis performed within 24 h of presentation were unremarkable. ACTH stimulation testing confirmed hypoadrenocorticism. Neurological signs failed to significantly improve despite systemic stabilization, glucose supplementation, and dexamethasone administration until approximately 48 h following admission. A mild proprioceptive ataxia was present at discharge approximately 84 h following admission and had resolved by the time of initial recheck 7 days following discharge.</p>\\n </section>\\n \\n <section>\\n \\n <h3> New Information Provided</h3>\\n \\n <p>EEH can cause neurological signs with forebrain localization that are typically symmetrical due to the global nature of the injury. To the authors’ knowledge, this is the first report of a dog with EEH presenting with severe, asymmetric, and multifocal neurological signs.</p>\\n </section>\\n </div>\",\"PeriodicalId\":17603,\"journal\":{\"name\":\"Journal of veterinary emergency and critical care\",\"volume\":\"35 4\",\"pages\":\"455-460\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of veterinary emergency and critical care\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/vec.70019\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of veterinary emergency and critical care","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/vec.70019","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Asymmetric Multifocal Neurological Signs in a Dog With Eunatremic, Eukalemic Hypoadrenocorticism With Severe Hypoglycemia
Objective
To describe the clinical presentation of a dog with eunatremic, eukalemic hypoadrenocorticism (EEH) with multifocal, asymmetrical neurological signs.
Case Summary
A 7-year-old neutered male miniature Poodle presented for collapse, vomiting, and acute onset of neurological signs. The dog was obtunded and nonambulatory, with a right-sided head tilt and turn with rotary nystagmus. No seizure activity was observed by the owner. The patient was in hypovolemic shock. Hypoglycemia, mild azotemia, and metabolic acidosis characterized by hyperlactatemia were identified. Magnetic resonance imaging of the brain and CSF analysis performed within 24 h of presentation were unremarkable. ACTH stimulation testing confirmed hypoadrenocorticism. Neurological signs failed to significantly improve despite systemic stabilization, glucose supplementation, and dexamethasone administration until approximately 48 h following admission. A mild proprioceptive ataxia was present at discharge approximately 84 h following admission and had resolved by the time of initial recheck 7 days following discharge.
New Information Provided
EEH can cause neurological signs with forebrain localization that are typically symmetrical due to the global nature of the injury. To the authors’ knowledge, this is the first report of a dog with EEH presenting with severe, asymmetric, and multifocal neurological signs.
期刊介绍:
The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues.
The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.