通过植入前非整倍体基因检测,一对夫妇复发性自然流产成功生下健康婴儿1例。

IF 2.9 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Frontiers in reproductive health Pub Date : 2025-08-08 eCollection Date: 2025-01-01 DOI:10.3389/frph.2025.1627160
Yuqin Zhu, Zhuoyao Mai, Ruiqi Li, Zaowen Liao, Nengyong Ouyang, Hui Chen, Haijing Zhao
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引用次数: 0

摘要

复发性自然流产(RSA)的特点是在妊娠28周之前发生三次或三次以上的流产,是辅助生殖医学领域的一个巨大挑战,在临床诊断和治疗方面都存在重大困难。近年来,RSA的发病率有明显的上升趋势,其病因是多方面和复杂的。精确定位RSA的根本原因仍然是一项艰巨的任务,迫切需要在生殖医学领域内解决。通过对rsa相关病例报告的全面深入分析,胚胎染色体异常被确定为最高危险因素。利用植入前非整倍体基因检测(PGT-A)技术,选择整倍体囊胚进行移植,成功怀孕并健康分娩。本病例对RSA的临床治疗具有重要的参考价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Successful live birth of a healthy infant by preimplantation genetic testing for aneuploidy in a couple with recurrent spontaneous abortion: a case report.

Successful live birth of a healthy infant by preimplantation genetic testing for aneuploidy in a couple with recurrent spontaneous abortion: a case report.

Recurrent spontaneous abortion (RSA), characterized by the occurrence of three or more pregnancy losses prior to the 28th week of gestation, stands as a formidable challenge in the realm of assisted reproductive medicine, presenting significant difficulties in both clinical diagnosis and treatment. In recent years, there has been a discernible upward trend in the incidence of RSA, and its etiology is multifaceted and intricate. Pinpointing the root causes of RSA remains an arduous task that urgently demands resolution within the field of reproductive medicine. Through a comprehensive and in-depth analysis of the RSA-related case report, embryonic chromosomal abnormalities were identified as the highest-risk factor. Utilizing preimplantation genetic testing for aneuploidy (PGT-A) technology, an euploid blastocyst was selected for transfer, which led to successful pregnancy and healthy birth. This case holds significant reference value for the clinical treatment of RSA.

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