{"title":"生活在pm2.5污染地区的高血压患者饮食模式和生活习惯与血管炎症反应之间的关系：泰国清迈省的一项横断面试点研究","authors":"Wason Parklak, Kanokwan Kulprachakarn, Sawaeng Kawichai, Puriwat Fakfum, Putita Jiraya, Praporn Kijkuokool, Wiritphon Khiaolaongam, Hataichanok Chuljerm","doi":"10.3390/diseases13080258","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/objectives: </strong>Exposure to fine particulate matter (PM<sub>2.5</sub>) is linked to increased cardiovascular risk, particularly in individuals with hypertension. This study examined the association between dietary patterns, lifestyle factors, and vascular inflammation among individuals with hypertension living in rural and peri-urban areas of Chiang Mai Province, Thailand.</p><p><strong>Methods: </strong>A cross-sectional pilot study was conducted among 47 participants (23 rural, 24 peri-urban). Data on dietary intake, smoking, alcohol use, anthropometry, and blood chemistry were collected. Serum intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and interleukin-6 (IL-6) were measured. Partial correlation analysis was used to examine associations with lifestyle factors, adjusting for relevant covariates.</p><p><strong>Results: </strong>Peri-urban participants had significantly higher levels of ICAM-1 [83.0 vs. 50.1 ng/mL], VCAM-1 [639.3 vs. 376.5 ng/mL], and IL-6 [4.80 vs. 1.02 pg/mL] compared to rural participants. Rural individuals reported higher intakes of antioxidant-related nutrients (selenium, β-carotene, niacin, vitamins A, B6, and C), while peri-urban individuals had higher sugar intake. Sugar intake was positively associated with ICAM-1 and VCAM-1, whereas selenium and vitamin C were inversely associated with both ICAM-1 and VCAM-1, while vitamin B6 was inversely associated with VCAM-1 only. Although rural participants had a higher rate of current smoking (34.8% vs. 4.4%), smoking and alcohol use were not significantly associated with inflammatory markers.</p><p><strong>Conclusion: </strong>Rural dietary patterns may be linked to reduced vascular adhesion molecule levels. Further studies with larger samples are warranted to clarify these associations and guide lifestyle strategies for managing vascular inflammation in PM<sub>2.5</sub>-exposed individuals with hypertension.</p>","PeriodicalId":72832,"journal":{"name":"Diseases (Basel, Switzerland)","volume":"13 8","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385977/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association Between Dietary Patterns and Lifestyle Habits with Vascular Inflammatory Responses in Individuals with Hypertension Living in PM<sub>2.5</sub>-Polluted Areas: A Cross-Sectional Pilot Study in Chiang Mai Province, Thailand.\",\"authors\":\"Wason Parklak, Kanokwan Kulprachakarn, Sawaeng Kawichai, Puriwat Fakfum, Putita Jiraya, Praporn Kijkuokool, Wiritphon Khiaolaongam, Hataichanok Chuljerm\",\"doi\":\"10.3390/diseases13080258\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/objectives: </strong>Exposure to fine particulate matter (PM<sub>2.5</sub>) is linked to increased cardiovascular risk, particularly in individuals with hypertension. This study examined the association between dietary patterns, lifestyle factors, and vascular inflammation among individuals with hypertension living in rural and peri-urban areas of Chiang Mai Province, Thailand.</p><p><strong>Methods: </strong>A cross-sectional pilot study was conducted among 47 participants (23 rural, 24 peri-urban). Data on dietary intake, smoking, alcohol use, anthropometry, and blood chemistry were collected. Serum intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and interleukin-6 (IL-6) were measured. Partial correlation analysis was used to examine associations with lifestyle factors, adjusting for relevant covariates.</p><p><strong>Results: </strong>Peri-urban participants had significantly higher levels of ICAM-1 [83.0 vs. 50.1 ng/mL], VCAM-1 [639.3 vs. 376.5 ng/mL], and IL-6 [4.80 vs. 1.02 pg/mL] compared to rural participants. Rural individuals reported higher intakes of antioxidant-related nutrients (selenium, β-carotene, niacin, vitamins A, B6, and C), while peri-urban individuals had higher sugar intake. Sugar intake was positively associated with ICAM-1 and VCAM-1, whereas selenium and vitamin C were inversely associated with both ICAM-1 and VCAM-1, while vitamin B6 was inversely associated with VCAM-1 only. Although rural participants had a higher rate of current smoking (34.8% vs. 4.4%), smoking and alcohol use were not significantly associated with inflammatory markers.</p><p><strong>Conclusion: </strong>Rural dietary patterns may be linked to reduced vascular adhesion molecule levels. Further studies with larger samples are warranted to clarify these associations and guide lifestyle strategies for managing vascular inflammation in PM<sub>2.5</sub>-exposed individuals with hypertension.</p>\",\"PeriodicalId\":72832,\"journal\":{\"name\":\"Diseases (Basel, Switzerland)\",\"volume\":\"13 8\",\"pages\":\"\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-08-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385977/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diseases (Basel, Switzerland)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/diseases13080258\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diseases (Basel, Switzerland)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/diseases13080258","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
摘要
背景/目的：暴露于细颗粒物（PM2.5）与心血管风险增加有关，尤其是高血压患者。本研究调查了生活在泰国清迈省农村和城郊地区的高血压患者饮食模式、生活方式因素和血管炎症之间的关系。方法：对47名参与者进行横断面初步研究（23名农村，24名城郊）。收集了饮食摄入、吸烟、饮酒、人体测量和血液化学的数据。测定血清细胞间粘附分子-1 （ICAM-1）、血管细胞粘附分子-1 （VCAM-1）、白细胞介素-6 （IL-6）水平。偏相关分析用于检查与生活方式因素的关联，调整相关协变量。结果：与农村参与者相比，城郊参与者的ICAM-1 [83.0 vs. 50.1 ng/mL]、VCAM-1 [639.3 vs. 376.5 ng/mL]和IL-6 [4.80 vs. 1.02 pg/mL]水平显著高于农村参与者。农村个体报告了较高的抗氧化相关营养素（硒、β-胡萝卜素、烟酸、维生素A、B6和C）摄入量，而城郊个体的糖摄入量较高。糖摄入量与ICAM-1和VCAM-1呈正相关，硒和维生素C与ICAM-1和VCAM-1均呈负相关，而维生素B6仅与VCAM-1呈负相关。尽管农村参与者的吸烟率较高（34.8%对4.4%），但吸烟和饮酒与炎症标志物没有显著相关性。结论：农村饮食模式可能与血管粘附分子水平降低有关。有必要开展更大样本的进一步研究，以澄清这些关联，并指导pm2.5暴露的高血压患者管理血管炎症的生活方式策略。
Association Between Dietary Patterns and Lifestyle Habits with Vascular Inflammatory Responses in Individuals with Hypertension Living in PM2.5-Polluted Areas: A Cross-Sectional Pilot Study in Chiang Mai Province, Thailand.
Background/objectives: Exposure to fine particulate matter (PM2.5) is linked to increased cardiovascular risk, particularly in individuals with hypertension. This study examined the association between dietary patterns, lifestyle factors, and vascular inflammation among individuals with hypertension living in rural and peri-urban areas of Chiang Mai Province, Thailand.
Methods: A cross-sectional pilot study was conducted among 47 participants (23 rural, 24 peri-urban). Data on dietary intake, smoking, alcohol use, anthropometry, and blood chemistry were collected. Serum intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and interleukin-6 (IL-6) were measured. Partial correlation analysis was used to examine associations with lifestyle factors, adjusting for relevant covariates.
Results: Peri-urban participants had significantly higher levels of ICAM-1 [83.0 vs. 50.1 ng/mL], VCAM-1 [639.3 vs. 376.5 ng/mL], and IL-6 [4.80 vs. 1.02 pg/mL] compared to rural participants. Rural individuals reported higher intakes of antioxidant-related nutrients (selenium, β-carotene, niacin, vitamins A, B6, and C), while peri-urban individuals had higher sugar intake. Sugar intake was positively associated with ICAM-1 and VCAM-1, whereas selenium and vitamin C were inversely associated with both ICAM-1 and VCAM-1, while vitamin B6 was inversely associated with VCAM-1 only. Although rural participants had a higher rate of current smoking (34.8% vs. 4.4%), smoking and alcohol use were not significantly associated with inflammatory markers.
Conclusion: Rural dietary patterns may be linked to reduced vascular adhesion molecule levels. Further studies with larger samples are warranted to clarify these associations and guide lifestyle strategies for managing vascular inflammation in PM2.5-exposed individuals with hypertension.
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