镜像还是分子幻影？乳腺癌脑转移中激素受体失调的研究。

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Journal of the Pakistan Medical Association Pub Date : 2025-08-01 DOI:10.47391/JPMA.25-65

Qurat Ul Ain Tariq, Eisha Abid Ali, Noman Ahmed, Irfan Yousaf, Muhammad Shahzad Shamim

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引用次数: 0

摘要

乳腺癌脑转移（BCBM）是一个重大的临床挑战，特别是在侵袭性亚型，如her2阳性和三阴性乳腺癌中。本文就激素受体失调的存在及其影响因素、血脑屏障（BBB）在转移进展中的作用以及治疗方法进行综述。虽然手术和放疗等局部治疗仍然是基础，但全身和免疫治疗方法的进展显示出很大的潜力。深入了解驱动BCBM的分子机制对于指导有效治疗和改善患者预后至关重要。

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Mirror Image or Molecular Mirage? Investigating Hormone Receptor Disconcordance in Breast Cancer Brain Metastases.

Breast cancer brain metastases (BCBM) are a significant clinical challenge, especially in aggressive subtypes like HER2-positive and triple-negative breast cancer. This review discusses hormone receptor discordance, it's existence and contributing factors, the role of the bloodbrain barrier (BBB) in metastatic progression, and therapeutic modalities. While local treatments such as surgery and radiotherapy remain foundational, advances in systemic and immunotherapeutic approaches show promising potential. A deeper understanding of molecular mechanisms driving BCBM is essential to guide effective treatments and improve patient outcomes.

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来源期刊

Journal of the Pakistan Medical Association Medicine-General Medicine

CiteScore

1.10

自引率

11.10%

发文量

983

审稿时长

3-6 weeks

期刊介绍： Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.