航天相关神经眼综合征的无创监测:对飞行方法需求的响应。

IF 4.1 1区 物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES
Elana A Meer, Lauren E Church, Benjamin A Johnson, James Rohde, Alexandra J Sinclair, Susan P Mollan, Lonnie Petersen, James D Polk, Aenor J Sawyer
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引用次数: 0

摘要

航天飞行相关的神经-眼综合征(SANS)影响宇航员的视力,在长时间任务期间和之后引起屈光和视力变化。随着太空机构计划扩展探索,实时SANS探测至关重要。对PubMed和EMBASE的系统回顾筛选了196项相关研究中的72项。目前的测量技术,包括有创和无创颅内压(ICP)评估和新技术,在量化SANS变化方面存在局限性,并且缺乏远程监测能力。诸如遥测ICP监测、光学相干层析成像(OCT)和超声等新兴工具显示出前景,但需要进一步验证。鉴于侵入性技术在空间中的局限性,非侵入性技术应在空间飞行实施之前在地面模拟物中进行测试。确切的SANS病因将决定最佳的监测方法,是icp为重点,眼为基础,还是两者结合。没有一种技术可以独立跟踪SANS进展,强调需要多参数集成和事后分析,以加强飞行中监测和缓解策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Non invasive monitoring for spaceflight associated neuro ocular syndrome: responding to a need for In flight methodologies.

Non invasive monitoring for spaceflight associated neuro ocular syndrome: responding to a need for In flight methodologies.

Spaceflight-Associated Neuro-Ocular Syndrome (SANS) affects astronaut vision, causing refraction and acuity changes during and after long-duration missions. As space agencies plan for extended exploration, real-time SANS detection is crucial. A systematic review of PubMed and EMBASE yielded 72 relevant studies out of 196 screened. Current measurement techniques, including invasive and noninvasive intracranial pressure (ICP) assessments and novel technologies, have limitations in quantifying SANS changes and lack remote monitoring capability. Emerging tools such as telemetric ICP monitoring, optical coherence tomography (OCT), and ultrasound show promise but require further validation. Given the constraints of invasive techniques in space, non-invasive technologies should be tested in terrestrial analogs before spaceflight implementation. The precise SANS etiology will determine optimal monitoring approaches, whether ICP-focused, ocular-based, or a combination of both. No single technology can independently track SANS progression, emphasizing the need for multiparametric integration and post hoc analysis to enhance in-flight monitoring and mitigation strategies.

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来源期刊
npj Microgravity
npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)
CiteScore
7.30
自引率
7.80%
发文量
50
审稿时长
9 weeks
期刊介绍: A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.
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