加速度计衍生的运动行为、遗传易感性与痴呆、死亡率和过早死亡风险之间的时间重新分配:一项纵向队列研究。

IF 5.5 1区 医学 Q1 NUTRITION & DIETETICS
Wenya Zhang, Yang Pan, Yiwen Dai, Jie Liang, Jingya Ma, Yuling Liu, Darui Gao, Yanyu Zhang, Mengmeng Ji, Wuxiang Xie, Fanfan Zheng
{"title":"加速度计衍生的运动行为、遗传易感性与痴呆、死亡率和过早死亡风险之间的时间重新分配:一项纵向队列研究。","authors":"Wenya Zhang, Yang Pan, Yiwen Dai, Jie Liang, Jingya Ma, Yuling Liu, Darui Gao, Yanyu Zhang, Mengmeng Ji, Wuxiang Xie, Fanfan Zheng","doi":"10.1186/s12966-025-01814-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>It is well established that all types of movement behaviors, including moderate-to-vigorous physical activity (MVPA), light-intensity physical activity (LIPA), sedentary behavior (SB), and sleep, are associated with the risk of incident dementia, all-cause mortality, and premature death. However, it remains unclear whether reallocating time from one type to another is associated with these outcomes. In addition, the extent to which genetic susceptibility modifies the association between physical activity and dementia risk still warrants further investigation.</p><p><strong>Methods: </strong>This study included 94 086 dementia-free participants from the UK Biobank with valid accelerometer and genomic data. Time spent MVPA, LIPA, SB, and sleep were derived from wrist-worn accelerometers. Genetic susceptibility of dementia was assessed by polygenic risk score (PRS) consisting of 82 single nucleotide polymorphisms. The isotemporal substitution model was applied to explore how reallocating time between movement behaviors was associated with incident dementia, mortality, and premature death.</p><p><strong>Results: </strong>Of 94 086 included participants, 52 853 (56.2%) were female, and the mean (standard deviation, SD) age was 62.3 (7.8) years. Reallocating 1 h/day to MVPA from LIPA, SB, and sleep was associated with a 19%, 26%, and 18% lower risk of incident dementia (adjusted hazard ratios [HRs] and 95% confidence intervals [CIs]: 0.81 [0.68, 0.95], 0.74 [0.63, 0.87], and 0.82 [0.69, 0.96], respectively). A 22%, 30%, and 29% reduced risk of mortality were observed when reallocating 1 h/day from LIPA, SB, and sleep to MVPA (0.78 [0.72, 0.84], 0.70 [0.65, 0.75], and 0.71 [0.66, 0.77], respectively). Replacing 1 h/day of SB with MVPA, LIPA, and sleep was associated with a 26%, 8%, and 9% lower risk of incident dementia (0.74 [0.63, 0.87], 0.92 [0.87, 0.97], and 0.91 [0.85, 0.97], respectively), and reallocating 1 h/day from SB to LIPA (0.89 [0.87-0.92]) or MVPA (0.70 [0.65-0.75]) was associated with reduced risk of mortality. Similar results could be seen in premature death. Participants with high levels of MVPA and low genetic risk showed 72% lower risk of dementia comparing to participants with low levels of MVPA and high PRS (0.28 [0.17-0.50]).</p><p><strong>Conclusions: </strong>Reallocating time to MVPA from any behavior and substituting physical activity of any intensity for SB were associated with decreased risks of incident dementia, mortality, and premature death, suggesting the significance of maintaining a physically active lifestyle among old adults. Moreover, increasing MVPA level could partially attenuate the strength of association between genetic susceptibility and the risk of dementia.</p>","PeriodicalId":50336,"journal":{"name":"International Journal of Behavioral Nutrition and Physical Activity","volume":"22 1","pages":"112"},"PeriodicalIF":5.5000,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369132/pdf/","citationCount":"0","resultStr":"{\"title\":\"Reallocation of time between accelerometer-derived movement behaviors, genetic susceptibility, and risk of incident dementia, mortality, and premature death: a longitudinal cohort study.\",\"authors\":\"Wenya Zhang, Yang Pan, Yiwen Dai, Jie Liang, Jingya Ma, Yuling Liu, Darui Gao, Yanyu Zhang, Mengmeng Ji, Wuxiang Xie, Fanfan Zheng\",\"doi\":\"10.1186/s12966-025-01814-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>It is well established that all types of movement behaviors, including moderate-to-vigorous physical activity (MVPA), light-intensity physical activity (LIPA), sedentary behavior (SB), and sleep, are associated with the risk of incident dementia, all-cause mortality, and premature death. However, it remains unclear whether reallocating time from one type to another is associated with these outcomes. In addition, the extent to which genetic susceptibility modifies the association between physical activity and dementia risk still warrants further investigation.</p><p><strong>Methods: </strong>This study included 94 086 dementia-free participants from the UK Biobank with valid accelerometer and genomic data. Time spent MVPA, LIPA, SB, and sleep were derived from wrist-worn accelerometers. Genetic susceptibility of dementia was assessed by polygenic risk score (PRS) consisting of 82 single nucleotide polymorphisms. The isotemporal substitution model was applied to explore how reallocating time between movement behaviors was associated with incident dementia, mortality, and premature death.</p><p><strong>Results: </strong>Of 94 086 included participants, 52 853 (56.2%) were female, and the mean (standard deviation, SD) age was 62.3 (7.8) years. Reallocating 1 h/day to MVPA from LIPA, SB, and sleep was associated with a 19%, 26%, and 18% lower risk of incident dementia (adjusted hazard ratios [HRs] and 95% confidence intervals [CIs]: 0.81 [0.68, 0.95], 0.74 [0.63, 0.87], and 0.82 [0.69, 0.96], respectively). A 22%, 30%, and 29% reduced risk of mortality were observed when reallocating 1 h/day from LIPA, SB, and sleep to MVPA (0.78 [0.72, 0.84], 0.70 [0.65, 0.75], and 0.71 [0.66, 0.77], respectively). Replacing 1 h/day of SB with MVPA, LIPA, and sleep was associated with a 26%, 8%, and 9% lower risk of incident dementia (0.74 [0.63, 0.87], 0.92 [0.87, 0.97], and 0.91 [0.85, 0.97], respectively), and reallocating 1 h/day from SB to LIPA (0.89 [0.87-0.92]) or MVPA (0.70 [0.65-0.75]) was associated with reduced risk of mortality. Similar results could be seen in premature death. Participants with high levels of MVPA and low genetic risk showed 72% lower risk of dementia comparing to participants with low levels of MVPA and high PRS (0.28 [0.17-0.50]).</p><p><strong>Conclusions: </strong>Reallocating time to MVPA from any behavior and substituting physical activity of any intensity for SB were associated with decreased risks of incident dementia, mortality, and premature death, suggesting the significance of maintaining a physically active lifestyle among old adults. Moreover, increasing MVPA level could partially attenuate the strength of association between genetic susceptibility and the risk of dementia.</p>\",\"PeriodicalId\":50336,\"journal\":{\"name\":\"International Journal of Behavioral Nutrition and Physical Activity\",\"volume\":\"22 1\",\"pages\":\"112\"},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2025-08-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369132/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Behavioral Nutrition and Physical Activity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12966-025-01814-8\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Behavioral Nutrition and Physical Activity","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12966-025-01814-8","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0

摘要

背景:所有类型的运动行为,包括中高强度身体活动(MVPA)、轻强度身体活动(LIPA)、久坐行为(SB)和睡眠,都与发生痴呆、全因死亡率和过早死亡的风险相关,这一点已经得到了充分的证实。然而,将时间从一种类型重新分配到另一种类型是否与这些结果有关尚不清楚。此外,遗传易感性在多大程度上改变了体育活动与痴呆风险之间的关联,仍有待进一步调查。方法:本研究纳入了来自英国生物银行的94086名无痴呆的参与者,他们具有有效的加速度计和基因组数据。MVPA、LIPA、SB和睡眠时间由腕带加速度计获得。采用由82个单核苷酸多态性组成的多基因风险评分(PRS)评估痴呆的遗传易感性。应用等时间替代模型来探索运动行为之间重新分配时间如何与痴呆、死亡率和过早死亡相关。结果:纳入的94086名参与者中,女性52853人(56.2%),平均(标准差,SD)年龄为62.3(7.8)岁。将1小时/天从LIPA、SB和睡眠中重新分配给MVPA,痴呆发生率降低19%、26%和18%(调整后的风险比[hr]和95%可信区间[ci]分别为0.81[0.68,0.95]、0.74[0.63,0.87]和0.82[0.69,0.96])。当将每天1小时的睡眠时间从LIPA、SB和睡眠时间重新分配给MVPA时,死亡率分别降低22%、30%和29%(分别为0.78[0.72,0.84]、0.70[0.65,0.75]和0.71[0.66,0.77])。用MVPA、LIPA和睡眠代替1小时/天的睡眠可降低26%、8%和9%的痴呆发生风险(分别为0.74[0.63,0.87]、0.92[0.87,0.97]和0.91[0.85,0.97]),将1小时/天的睡眠重新分配给LIPA(0.89[0.87-0.92]或MVPA(0.70[0.65-0.75])可降低死亡风险。在过早死亡中也可以看到类似的结果。与低MVPA水平和高PRS水平的参与者相比,高MVPA水平和低遗传风险的参与者患痴呆的风险降低了72%(0.28[0.17-0.50])。结论:将时间从任何行为中重新分配到MVPA中,并以任何强度的体育活动替代SB,都与降低痴呆、死亡率和过早死亡的风险相关,这表明在老年人中保持体育活动的生活方式具有重要意义。此外,增加MVPA水平可以部分减弱遗传易感性与痴呆风险之间的关联强度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Reallocation of time between accelerometer-derived movement behaviors, genetic susceptibility, and risk of incident dementia, mortality, and premature death: a longitudinal cohort study.

Reallocation of time between accelerometer-derived movement behaviors, genetic susceptibility, and risk of incident dementia, mortality, and premature death: a longitudinal cohort study.

Reallocation of time between accelerometer-derived movement behaviors, genetic susceptibility, and risk of incident dementia, mortality, and premature death: a longitudinal cohort study.

Background: It is well established that all types of movement behaviors, including moderate-to-vigorous physical activity (MVPA), light-intensity physical activity (LIPA), sedentary behavior (SB), and sleep, are associated with the risk of incident dementia, all-cause mortality, and premature death. However, it remains unclear whether reallocating time from one type to another is associated with these outcomes. In addition, the extent to which genetic susceptibility modifies the association between physical activity and dementia risk still warrants further investigation.

Methods: This study included 94 086 dementia-free participants from the UK Biobank with valid accelerometer and genomic data. Time spent MVPA, LIPA, SB, and sleep were derived from wrist-worn accelerometers. Genetic susceptibility of dementia was assessed by polygenic risk score (PRS) consisting of 82 single nucleotide polymorphisms. The isotemporal substitution model was applied to explore how reallocating time between movement behaviors was associated with incident dementia, mortality, and premature death.

Results: Of 94 086 included participants, 52 853 (56.2%) were female, and the mean (standard deviation, SD) age was 62.3 (7.8) years. Reallocating 1 h/day to MVPA from LIPA, SB, and sleep was associated with a 19%, 26%, and 18% lower risk of incident dementia (adjusted hazard ratios [HRs] and 95% confidence intervals [CIs]: 0.81 [0.68, 0.95], 0.74 [0.63, 0.87], and 0.82 [0.69, 0.96], respectively). A 22%, 30%, and 29% reduced risk of mortality were observed when reallocating 1 h/day from LIPA, SB, and sleep to MVPA (0.78 [0.72, 0.84], 0.70 [0.65, 0.75], and 0.71 [0.66, 0.77], respectively). Replacing 1 h/day of SB with MVPA, LIPA, and sleep was associated with a 26%, 8%, and 9% lower risk of incident dementia (0.74 [0.63, 0.87], 0.92 [0.87, 0.97], and 0.91 [0.85, 0.97], respectively), and reallocating 1 h/day from SB to LIPA (0.89 [0.87-0.92]) or MVPA (0.70 [0.65-0.75]) was associated with reduced risk of mortality. Similar results could be seen in premature death. Participants with high levels of MVPA and low genetic risk showed 72% lower risk of dementia comparing to participants with low levels of MVPA and high PRS (0.28 [0.17-0.50]).

Conclusions: Reallocating time to MVPA from any behavior and substituting physical activity of any intensity for SB were associated with decreased risks of incident dementia, mortality, and premature death, suggesting the significance of maintaining a physically active lifestyle among old adults. Moreover, increasing MVPA level could partially attenuate the strength of association between genetic susceptibility and the risk of dementia.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
13.80
自引率
3.40%
发文量
138
审稿时长
4-8 weeks
期刊介绍: International Journal of Behavioral Nutrition and Physical Activity (IJBNPA) is an open access, peer-reviewed journal offering high quality articles, rapid publication and wide diffusion in the public domain. IJBNPA is devoted to furthering the understanding of the behavioral aspects of diet and physical activity and is unique in its inclusion of multiple levels of analysis, including populations, groups and individuals and its inclusion of epidemiology, and behavioral, theoretical and measurement research areas.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信