Carlos Cantú-Brito, Manuel Alfonso Baños-González, Jesus Antonio González-Hermosillo, Milton Ernesto Guevara-Valdivia, Jorge Abel Vázquez-Acosta, José Luis Leiva-Pons, Alejandro Lechuga-Martin Del Campo, Humberto Rodríguez-Reyes, Janneth Manzano-Cabada, Manlio Fabio Márquez-Murillo, Manuel Odín de Los Ríos-Ibarra, Julio Alberto Aguilar-Linares, Gerardo Pozas-Garza, Eddie Alberto Favela-Pérez, Luis Molina-Fernández de Lara, Reynaldo Magaña Magaña, Rocío Camacho-Casillas, Cesar Vásquez-Serna, Norberto Matadamas-Hernández, Ulises Rojel-Martínez, Miguel Negrete-Rivera, Héctor Fernández-Saldaña, Marco Islava-Galvez, Lidia Betancourt-Hernández, Demetrio Kosturakis-García, Alberto Baños-Velasco, Miguel Beltrán-Gámez, Susano Lara-Vaca, José Luis Novelo-Del Valle, Luis Delgado-Leal, Luis Trujillo-Muñoz, Raúl Isaac-Márquez, Enrique Martínez-Flores, Nicolás Reyes-Reyes, Ramón Miguel Esturau-Santaló, José Fabián Hernández-Díaz, Juan Carlos Núñez-Fragoso, José Manuel Enciso Muñoz, María Isabel Sánchez-Ramírez
{"title":"墨西哥有脑血管病史的非瓣膜性心房颤动患者的次优口服抗凝CARMEN-AF Registry的结果。","authors":"Carlos Cantú-Brito, Manuel Alfonso Baños-González, Jesus Antonio González-Hermosillo, Milton Ernesto Guevara-Valdivia, Jorge Abel Vázquez-Acosta, José Luis Leiva-Pons, Alejandro Lechuga-Martin Del Campo, Humberto Rodríguez-Reyes, Janneth Manzano-Cabada, Manlio Fabio Márquez-Murillo, Manuel Odín de Los Ríos-Ibarra, Julio Alberto Aguilar-Linares, Gerardo Pozas-Garza, Eddie Alberto Favela-Pérez, Luis Molina-Fernández de Lara, Reynaldo Magaña Magaña, Rocío Camacho-Casillas, Cesar Vásquez-Serna, Norberto Matadamas-Hernández, Ulises Rojel-Martínez, Miguel Negrete-Rivera, Héctor Fernández-Saldaña, Marco Islava-Galvez, Lidia Betancourt-Hernández, Demetrio Kosturakis-García, Alberto Baños-Velasco, Miguel Beltrán-Gámez, Susano Lara-Vaca, José Luis Novelo-Del Valle, Luis Delgado-Leal, Luis Trujillo-Muñoz, Raúl Isaac-Márquez, Enrique Martínez-Flores, Nicolás Reyes-Reyes, Ramón Miguel Esturau-Santaló, José Fabián Hernández-Díaz, Juan Carlos Núñez-Fragoso, José Manuel Enciso Muñoz, María Isabel Sánchez-Ramírez","doi":"10.1016/j.ric.2025.100003","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) increases the risk of stroke, especially in patients with previous cerebrovascular disease. This risk is significantly reduced with oral anticoagulants (OAC), with direct oral anticoagulants (DOACs) being the optimal treatment.</p><p><strong>Objectives: </strong>To study the most used anticoagulant treatment in patients with nonvalvular AF (NVAF) with and without cerebrovascular disease in Mexico.</p><p><strong>Methods: </strong>CARMEN-AF is a national, multicentric observational registry that includes 1423 patients with AF. Patients were recruited regardless of the anticoagulant therapy. Demographics, clinical variables, comorbidities and antithrombotic treatment were compared among patients with and without a history of cerebrovascular disease.</p><p><strong>Results: </strong>Of the 238 patients with a previous cerebrovascular disease (average age 69±13 years; 114 women [48.5%]), 99% had a previous ischemic stroke. In this subgroup, the type of AF was permanent 43.4%, persistent 20%, and paroxysmal AF was 36.6%. Principal comorbidities were hypertension 77.9%, diabetes mellitus 29.8%, and heart failure 20%. Nearly 12.4% of patients with a history of ischemic cerebrovascular disease did not receive anticoagulant (AC) treatment. Among those who did, vitamin K antagonists (VKAs) were more commonly prescribed than DOACs (37.4% vs. 25.5%).</p><p><strong>Conclusion: </strong>In Mexico, anticoagulation rates remain low among patients with NVAF and a history of cerebrovascular disease.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"77 3","pages":"100003"},"PeriodicalIF":1.4000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Suboptimal oral anticoagulation in patients with nonvalvular atrial fibrillation and history of cerebrovascular disease in Mexico. Results from CARMEN-AF Registry.\",\"authors\":\"Carlos Cantú-Brito, Manuel Alfonso Baños-González, Jesus Antonio González-Hermosillo, Milton Ernesto Guevara-Valdivia, Jorge Abel Vázquez-Acosta, José Luis Leiva-Pons, Alejandro Lechuga-Martin Del Campo, Humberto Rodríguez-Reyes, Janneth Manzano-Cabada, Manlio Fabio Márquez-Murillo, Manuel Odín de Los Ríos-Ibarra, Julio Alberto Aguilar-Linares, Gerardo Pozas-Garza, Eddie Alberto Favela-Pérez, Luis Molina-Fernández de Lara, Reynaldo Magaña Magaña, Rocío Camacho-Casillas, Cesar Vásquez-Serna, Norberto Matadamas-Hernández, Ulises Rojel-Martínez, Miguel Negrete-Rivera, Héctor Fernández-Saldaña, Marco Islava-Galvez, Lidia Betancourt-Hernández, Demetrio Kosturakis-García, Alberto Baños-Velasco, Miguel Beltrán-Gámez, Susano Lara-Vaca, José Luis Novelo-Del Valle, Luis Delgado-Leal, Luis Trujillo-Muñoz, Raúl Isaac-Márquez, Enrique Martínez-Flores, Nicolás Reyes-Reyes, Ramón Miguel Esturau-Santaló, José Fabián Hernández-Díaz, Juan Carlos Núñez-Fragoso, José Manuel Enciso Muñoz, María Isabel Sánchez-Ramírez\",\"doi\":\"10.1016/j.ric.2025.100003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Atrial fibrillation (AF) increases the risk of stroke, especially in patients with previous cerebrovascular disease. This risk is significantly reduced with oral anticoagulants (OAC), with direct oral anticoagulants (DOACs) being the optimal treatment.</p><p><strong>Objectives: </strong>To study the most used anticoagulant treatment in patients with nonvalvular AF (NVAF) with and without cerebrovascular disease in Mexico.</p><p><strong>Methods: </strong>CARMEN-AF is a national, multicentric observational registry that includes 1423 patients with AF. Patients were recruited regardless of the anticoagulant therapy. Demographics, clinical variables, comorbidities and antithrombotic treatment were compared among patients with and without a history of cerebrovascular disease.</p><p><strong>Results: </strong>Of the 238 patients with a previous cerebrovascular disease (average age 69±13 years; 114 women [48.5%]), 99% had a previous ischemic stroke. In this subgroup, the type of AF was permanent 43.4%, persistent 20%, and paroxysmal AF was 36.6%. Principal comorbidities were hypertension 77.9%, diabetes mellitus 29.8%, and heart failure 20%. Nearly 12.4% of patients with a history of ischemic cerebrovascular disease did not receive anticoagulant (AC) treatment. Among those who did, vitamin K antagonists (VKAs) were more commonly prescribed than DOACs (37.4% vs. 25.5%).</p><p><strong>Conclusion: </strong>In Mexico, anticoagulation rates remain low among patients with NVAF and a history of cerebrovascular disease.</p>\",\"PeriodicalId\":49612,\"journal\":{\"name\":\"Revista De Investigacion Clinica-Clinical and Translational Investigation\",\"volume\":\"77 3\",\"pages\":\"100003\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista De Investigacion Clinica-Clinical and Translational Investigation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ric.2025.100003\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista De Investigacion Clinica-Clinical and Translational Investigation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ric.2025.100003","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/2 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Suboptimal oral anticoagulation in patients with nonvalvular atrial fibrillation and history of cerebrovascular disease in Mexico. Results from CARMEN-AF Registry.
Background: Atrial fibrillation (AF) increases the risk of stroke, especially in patients with previous cerebrovascular disease. This risk is significantly reduced with oral anticoagulants (OAC), with direct oral anticoagulants (DOACs) being the optimal treatment.
Objectives: To study the most used anticoagulant treatment in patients with nonvalvular AF (NVAF) with and without cerebrovascular disease in Mexico.
Methods: CARMEN-AF is a national, multicentric observational registry that includes 1423 patients with AF. Patients were recruited regardless of the anticoagulant therapy. Demographics, clinical variables, comorbidities and antithrombotic treatment were compared among patients with and without a history of cerebrovascular disease.
Results: Of the 238 patients with a previous cerebrovascular disease (average age 69±13 years; 114 women [48.5%]), 99% had a previous ischemic stroke. In this subgroup, the type of AF was permanent 43.4%, persistent 20%, and paroxysmal AF was 36.6%. Principal comorbidities were hypertension 77.9%, diabetes mellitus 29.8%, and heart failure 20%. Nearly 12.4% of patients with a history of ischemic cerebrovascular disease did not receive anticoagulant (AC) treatment. Among those who did, vitamin K antagonists (VKAs) were more commonly prescribed than DOACs (37.4% vs. 25.5%).
Conclusion: In Mexico, anticoagulation rates remain low among patients with NVAF and a history of cerebrovascular disease.
期刊介绍：
The Revista de Investigación Clínica – Clinical and Translational Investigation (RIC-C&TI), publishes original clinical and biomedical research of interest to physicians in internal medicine, surgery, and any of their specialties. The Revista de Investigación Clínica – Clinical and Translational Investigation is the official journal of the National Institutes of Health of Mexico, which comprises a group of Institutes and High Specialty Hospitals belonging to the Ministery of Health. The journal is published both on-line and in printed version, appears bimonthly and publishes peer-reviewed original research articles as well as brief and in-depth reviews. All articles published are open access and can be immediately and permanently free for everyone to read and download. The journal accepts clinical and molecular research articles, short reports and reviews.
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