Timothy W Neal, Sayyed Mohseni, Victoria Ratcliffe, Thomas Schlieve
{"title":"儿科患者抗吸收治疗前是否有必要清除牙齿？","authors":"Timothy W Neal, Sayyed Mohseni, Victoria Ratcliffe, Thomas Schlieve","doi":"10.1016/j.oooo.2025.07.015","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to determine if there was a difference in the frequency of medication-related osteonecrosis of the jaws (MRONJ) between pediatric patients who obtained dental clearance and those who didn't obtain dental clearance before the start of antiresorptive therapy. The secondary aim was to assess the effect of dental clearance on future dental follow-up after the start of antiresorptive treatment.</p><p><strong>Materials and methods: </strong>The study population was composed of patients less than 18 years of age who received antiresorptive treatment from 2010 to 2024 at Children's Medical Center Dallas.</p><p><strong>Results: </strong>There were 88 subjects in the clearance group and 48 in the no-clearance group. No cases of MRONJ were observed in either group. The clearance group mean dental visits per year after the start of antiresorptive therapy was 1.21 (SD 0.96), and 0.55 (0.65) for the no-clearance group. There was a significant difference between the two groups (P = .0002).</p><p><strong>Discussion: </strong>No cases of MRONJ were observed in the present study. In pediatric patients who receive dental clearance prior to the start of antiresorptive medications, there is an association with continued routine dental follow-up.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Is dental clearance necessary before antiresorptive treatment in pediatric patients?\",\"authors\":\"Timothy W Neal, Sayyed Mohseni, Victoria Ratcliffe, Thomas Schlieve\",\"doi\":\"10.1016/j.oooo.2025.07.015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>This study aimed to determine if there was a difference in the frequency of medication-related osteonecrosis of the jaws (MRONJ) between pediatric patients who obtained dental clearance and those who didn't obtain dental clearance before the start of antiresorptive therapy. The secondary aim was to assess the effect of dental clearance on future dental follow-up after the start of antiresorptive treatment.</p><p><strong>Materials and methods: </strong>The study population was composed of patients less than 18 years of age who received antiresorptive treatment from 2010 to 2024 at Children's Medical Center Dallas.</p><p><strong>Results: </strong>There were 88 subjects in the clearance group and 48 in the no-clearance group. No cases of MRONJ were observed in either group. The clearance group mean dental visits per year after the start of antiresorptive therapy was 1.21 (SD 0.96), and 0.55 (0.65) for the no-clearance group. There was a significant difference between the two groups (P = .0002).</p><p><strong>Discussion: </strong>No cases of MRONJ were observed in the present study. In pediatric patients who receive dental clearance prior to the start of antiresorptive medications, there is an association with continued routine dental follow-up.</p>\",\"PeriodicalId\":49010,\"journal\":{\"name\":\"Oral Surgery Oral Medicine Oral Pathology Oral Radiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral Surgery Oral Medicine Oral Pathology Oral Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.oooo.2025.07.015\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.oooo.2025.07.015","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Is dental clearance necessary before antiresorptive treatment in pediatric patients?
Introduction: This study aimed to determine if there was a difference in the frequency of medication-related osteonecrosis of the jaws (MRONJ) between pediatric patients who obtained dental clearance and those who didn't obtain dental clearance before the start of antiresorptive therapy. The secondary aim was to assess the effect of dental clearance on future dental follow-up after the start of antiresorptive treatment.
Materials and methods: The study population was composed of patients less than 18 years of age who received antiresorptive treatment from 2010 to 2024 at Children's Medical Center Dallas.
Results: There were 88 subjects in the clearance group and 48 in the no-clearance group. No cases of MRONJ were observed in either group. The clearance group mean dental visits per year after the start of antiresorptive therapy was 1.21 (SD 0.96), and 0.55 (0.65) for the no-clearance group. There was a significant difference between the two groups (P = .0002).
Discussion: No cases of MRONJ were observed in the present study. In pediatric patients who receive dental clearance prior to the start of antiresorptive medications, there is an association with continued routine dental follow-up.
期刊介绍：
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.
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