Utilisation of the Malaysian BRCA variants database to construct a target panel for biosensor-based genetic breast cancer screening.

Breast cancer remains a significant health concern, particularly in Malaysia, where it stands as the most prevalent cancer among women. The BRCA, implicated in inherited breast cancer syndromes, has garnered considerable attention due to its role in tumorigenesis. Utilising next-generation sequencing and bioinformatic tools, researchers have compiled a comprehensive database of BRCA variants specific to the Malaysian population. This article reviews the distribution of these variants across different ethnic groups in Malaysia and explores their implications for biosensor development. By leveraging this database, researchers aim to construct biorecognition elements for electrochemical biosensors, enabling affordable and accessible genetic screening for breast cancer mutations. The article underscores the importance of adhering to technical standards and considering ethnic diversity in selecting biorecognition elements. Ultimately, the integration of Malaysian BRCA variants into biosensor technology holds promise for enhancing early detection and improving clinical management of breast cancer in the Malaysian population.