代谢功能障碍相关脂肪变性肝病患者健康睡眠模式与心血管疾病、肝脏相关事件和全因死亡率的风险：一项大型前瞻性队列研究

IF 3.4 2区医学 Q2 CLINICAL NEUROLOGY

Sleep Health Pub Date : 2025-08-22 DOI:10.1016/j.sleh.2025.07.007

Shijia Wang MB , Yingxin Liao MB , Yuqing Deng MD, PhD , Chao Yu MD, PhD , Xuechen Chen MD, PhD , Xinyu Liu MB , Qiaoqiao Yang MB , Ke Chen MD, PhD , Xu Chen MD, PhD , Hongliang Xue MD, PhD

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引用次数: 0

摘要

目的：本研究旨在调查代谢功能障碍相关脂肪变性肝病患者整体健康睡眠模式与心血管疾病、肝脏相关事件和全因死亡率之间的关系。方法：该队列研究包括来自英国生物银行的123228名患有代谢功能障碍相关脂肪变性肝病的参与者，他们在基线时进行了详细的睡眠评估。健康睡眠模式是通过综合健康睡眠评分构建的，该评分包含了不同的睡眠行为。从医院住院记录和死亡登记系统中确定心血管疾病、肝脏相关事件和全因死亡率。Cox比例风险模型和受限三次样条用于估计风险比和95%置信区间（ci）。结果：在15.45人年的随访中，我们记录了20,287例心血管疾病事件，1304例肝脏相关事件，10306例代谢功能障碍相关脂肪变性肝病患者死亡。与睡眠模式较差的参与者相比，健康睡眠模式的参与者心血管疾病的多变量调整风险比为0.72 (95% CI, 0.67-0.77)，肝脏相关事件的多变量调整风险比为0.73 (95% CI, 0.57-0.94)，全因死亡率的多变量调整风险比为0.87 （95% CI, 0.79-0.96）。限制三次样条表明，健康睡眠评分与代谢功能障碍相关脂肪变性肝病患者的心血管疾病、肝脏相关事件和全因死亡率之间存在显著的线性关联。结论：我们的研究结果表明，保持健康睡眠模式的代谢功能障碍相关脂肪变性肝病患者心血管疾病、肝脏相关事件和死亡率的风险较低，强调了良好的睡眠模式在预防代谢功能障碍相关脂肪变性肝病患者肝内/肝外事件中的重要性。

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Healthy sleep patterns and risk of incident cardiovascular disease, liver-related events, and all-cause mortality among individuals with metabolic dysfunction--associated steatotic liver disease: A large prospective cohort study

Objectives

This study aimed to investigate the association between overall healthy sleep patterns and cardiovascular disease, liver-related events, and all-cause mortality among individuals with metabolic dysfunction--associated steatotic liver disease.

Methods

This cohort study included 123,228 participants with metabolic dysfunction--associated steatotic liver disease from the UK Biobank, who had detailed sleep assessment at baseline. The healthy sleep pattern was constructed by a composite healthy sleep score that incorporated different sleep behaviors. Incident cardiovascular disease, liver-related events, and all-cause mortality were identified from hospital inpatient records and death register systems. Cox proportional hazards models and restricted cubic splines were applied to estimate hazard ratios and 95% confidence intervals (CIs).

Results

During a 15.45 person-years of follow-up, we recorded 20,287 cardiovascular disease events, 1304 liver-related events, and 10,306 deaths in patients with metabolic dysfunction--associated steatotic liver disease. Compared with participants with a poor sleep pattern, the multivariable-adjusted hazard ratios for participants with a healthy sleep pattern were 0.72 (95% CI, 0.67-0.77) for cardiovascular disease, 0.73 (95% CI, 0.57-0.94) for liver-related events, and 0.87 (95% CI, 0.79-0.96) for all-cause mortality. Restricted cubic splines indicated a significant linear association between healthy sleep scores and cardiovascular disease, liver-related events, and all-cause mortality in patients with metabolic dysfunction--associated steatotic liver disease.

Conclusions

Our findings suggest that patients with metabolic dysfunction--associated steatotic liver disease who maintained healthy sleep patterns were associated with a lower risk of cardiovascular disease, liver-related events, and mortality, highlighting the importance of favorable sleep patterns in the prevention of intrahepatic/extrahepatic events in individuals with metabolic dysfunction--associated steatotic liver disease.

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来源期刊

Sleep Health CLINICAL NEUROLOGY-

CiteScore

6.30

自引率

9.80%

发文量

114

审稿时长

54 days

期刊介绍： Sleep Health Journal of the National Sleep Foundation is a multidisciplinary journal that explores sleep''s role in population health and elucidates the social science perspective on sleep and health. Aligned with the National Sleep Foundation''s global authoritative, evidence-based voice for sleep health, the journal serves as the foremost publication for manuscripts that advance the sleep health of all members of society.The scope of the journal extends across diverse sleep-related fields, including anthropology, education, health services research, human development, international health, law, mental health, nursing, nutrition, psychology, public health, public policy, fatigue management, transportation, social work, and sociology. The journal welcomes original research articles, review articles, brief reports, special articles, letters to the editor, editorials, and commentaries.