Anitha M Barney, Barney Isaac, Balamugesh Thangakunam, Sumita Danda, Debashish Danda, Venkata R Mohan, Christhunesa S Christudass, Devasahayam J Christopher
{"title":"印度南部三级医疗机构特发性肺纤维化患者的健康相关生活质量(HRQoL)及其预测因素","authors":"Anitha M Barney, Barney Isaac, Balamugesh Thangakunam, Sumita Danda, Debashish Danda, Venkata R Mohan, Christhunesa S Christudass, Devasahayam J Christopher","doi":"10.4103/lungindia.lungindia_591_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objectives: </strong>Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive Interstitial lung disease (ILD) that has a significant impact on the health-related quality of life (HRQoL). There are generic and disease-specific questionnaires to assess this, but no literature from India exists.</p><p><strong>Hence we decided: </strong>to estimate HRQoL and to determine its predictors in a cohort of patients attending a tertiary care centre in Southern India.</p><p><strong>Methods: </strong>Consecutive consenting patients diagnosed with IPF by the ILD MDD between September 2023 and August 2024 were self-administered the St. George's Respiratory Questionnaire (SGRQ) and the King's Brief Interstitial Lung Disease (KBILD) questionnaire to assess the HRQoL.</p><p><strong>Results: </strong>In all, 70 patients with IPF were recruited into the study. The median total SGRQ was 35.9 (23.9-57.8), and the median total KBILD was 54.5 (46.4-65.6). Based on SGRQ (>30), 63% (44/70) and based on KBILD (≤50), 34% (24/70) had a poor quality of life. The SGRQ was significantly lower in those not on antifibrotics across all domains, with a trend towards near significance in the activity domain. The Gender, Age, Physiology (GAP) Index had a significant association with the KBILD - breathlessness and activity domain (P value = 0.01) and the total score (P value = 0.02).</p><p><strong>Conclusion: </strong>This is the first Indian study reporting HRQoL in IPF. IPF impacts HRQoL drastically, with a predominant impact on physical wellness and a lesser effect on psychological well-being. KBILD is associated with the GAP index. A larger study is required to identify independent factors associated with HRQoL.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 5","pages":"421-428"},"PeriodicalIF":1.2000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453537/pdf/","citationCount":"0","resultStr":"{\"title\":\"Health-related quality of life (HRQoL) and its predictors among patients with Idiopathic pulmonary fibrosis attending a tertiary care setting in Southern India.\",\"authors\":\"Anitha M Barney, Barney Isaac, Balamugesh Thangakunam, Sumita Danda, Debashish Danda, Venkata R Mohan, Christhunesa S Christudass, Devasahayam J Christopher\",\"doi\":\"10.4103/lungindia.lungindia_591_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objectives: </strong>Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive Interstitial lung disease (ILD) that has a significant impact on the health-related quality of life (HRQoL). There are generic and disease-specific questionnaires to assess this, but no literature from India exists.</p><p><strong>Hence we decided: </strong>to estimate HRQoL and to determine its predictors in a cohort of patients attending a tertiary care centre in Southern India.</p><p><strong>Methods: </strong>Consecutive consenting patients diagnosed with IPF by the ILD MDD between September 2023 and August 2024 were self-administered the St. George's Respiratory Questionnaire (SGRQ) and the King's Brief Interstitial Lung Disease (KBILD) questionnaire to assess the HRQoL.</p><p><strong>Results: </strong>In all, 70 patients with IPF were recruited into the study. The median total SGRQ was 35.9 (23.9-57.8), and the median total KBILD was 54.5 (46.4-65.6). Based on SGRQ (>30), 63% (44/70) and based on KBILD (≤50), 34% (24/70) had a poor quality of life. The SGRQ was significantly lower in those not on antifibrotics across all domains, with a trend towards near significance in the activity domain. The Gender, Age, Physiology (GAP) Index had a significant association with the KBILD - breathlessness and activity domain (P value = 0.01) and the total score (P value = 0.02).</p><p><strong>Conclusion: </strong>This is the first Indian study reporting HRQoL in IPF. IPF impacts HRQoL drastically, with a predominant impact on physical wellness and a lesser effect on psychological well-being. KBILD is associated with the GAP index. A larger study is required to identify independent factors associated with HRQoL.</p>\",\"PeriodicalId\":47462,\"journal\":{\"name\":\"Lung India\",\"volume\":\"42 5\",\"pages\":\"421-428\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453537/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lung India\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/lungindia.lungindia_591_24\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lung India","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/lungindia.lungindia_591_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/2 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Health-related quality of life (HRQoL) and its predictors among patients with Idiopathic pulmonary fibrosis attending a tertiary care setting in Southern India.
Background and objectives: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive Interstitial lung disease (ILD) that has a significant impact on the health-related quality of life (HRQoL). There are generic and disease-specific questionnaires to assess this, but no literature from India exists.
Hence we decided: to estimate HRQoL and to determine its predictors in a cohort of patients attending a tertiary care centre in Southern India.
Methods: Consecutive consenting patients diagnosed with IPF by the ILD MDD between September 2023 and August 2024 were self-administered the St. George's Respiratory Questionnaire (SGRQ) and the King's Brief Interstitial Lung Disease (KBILD) questionnaire to assess the HRQoL.
Results: In all, 70 patients with IPF were recruited into the study. The median total SGRQ was 35.9 (23.9-57.8), and the median total KBILD was 54.5 (46.4-65.6). Based on SGRQ (>30), 63% (44/70) and based on KBILD (≤50), 34% (24/70) had a poor quality of life. The SGRQ was significantly lower in those not on antifibrotics across all domains, with a trend towards near significance in the activity domain. The Gender, Age, Physiology (GAP) Index had a significant association with the KBILD - breathlessness and activity domain (P value = 0.01) and the total score (P value = 0.02).
Conclusion: This is the first Indian study reporting HRQoL in IPF. IPF impacts HRQoL drastically, with a predominant impact on physical wellness and a lesser effect on psychological well-being. KBILD is associated with the GAP index. A larger study is required to identify independent factors associated with HRQoL.