局部输送1%二甲双胍凝胶改善牙周参数:一项系统回顾和荟萃分析。

IF 2.3 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Kata Sára Haba, Bulcsú Bencze, Gábor Kammerhofer, Márta Ujpál, Dorottya Bányai, Péter Hermann, Sarolta Antal, Klaudia Lipták, Laura Lipták, Zoltán Géczi, Tamás Hegedüs, Ádám Végh, Dóra Haluszka, Dániel Végh, Hamdan Alghamdi
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引用次数: 0

摘要

目的:全球大约19%的成年人受到牙周病的影响。治疗是一个长期的过程,受患者的动机、熟练程度和配合程度的显著影响。糖尿病患者牙周病患病率极高,且呈双向关系。在以前的研究中,二甲双胍(MF),一种双胍类抗糖尿病药物,在局部给药治疗牙周缺陷时显示出有希望的结果。本研究旨在系统地评估现有文献,评估1%二甲双胍凝胶治疗牙周病的有效性。我们试图纳入与安慰剂相比,局部给予1%二甲双胍凝胶治疗牙周炎患者的临床试验。方法:使用相同的MeSH术语,在三个数据库中进行系统检索。我们的分析包括测量牙周袋深度、临床附着水平和骨内缺损深度的人类研究。采用随机效应模型进行meta分析,比较研究组与对照组之间的平均差异。研究组在常规治疗的基础上局部接受1% MF凝胶治疗,对照组在常规治疗的基础上接受安慰剂治疗。结果:根据选择程序,从系统检索确定的246篇文章中选择了6篇文章纳入我们的荟萃分析。经过3个月和6个月的随访,荟萃分析显示对照组和研究组之间存在统计学上的显著差异。PD的总体效果是减少1.33 mm(95%置信区间(CI): -1.66;3个月后为-1.01毫米,6个月后为1.87毫米(-2.24毫米,-1.39毫米)。3个月后CAL的总疗效为1.80 mm(-2.26; -1.34), 6个月后为2.14 mm(-2.71; -1.58)。六个月随访后,IBD的变化为1.16 mm(-1.40; -0.92)。结论:1% MF凝胶配合常规治疗可促进牙周病的愈合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Locally delivered 1% metformin gel improves periodontal parameters: A systematic review and meta-analysis.

Locally delivered 1% metformin gel improves periodontal parameters: A systematic review and meta-analysis.

Locally delivered 1% metformin gel improves periodontal parameters: A systematic review and meta-analysis.

Locally delivered 1% metformin gel improves periodontal parameters: A systematic review and meta-analysis.

Purpose: Approximately 19% of the global adult population is affected by periodontal diseases. Healing is a protracted process that is significantly influenced by the patient's motivation, proficiency, and cooperation. The prevalence of periodontal diseases in patients with diabetes mellitus is extremely high, and the relationship is bidirectional. In previous investigations, metformin (MF), a biguanide antidiabetic medicine, has demonstrated promising results when administered locally to periodontal defects. The study aimed to systematically assess available literature that evaluate the effectiveness of 1% metformin gel in the treatment of periodontal disease. We attempted to include clinical trials on patients with periodontitis treated with local administration of 1% metformin gel, compared to a placebo.

Methods: Using identical MeSH terms, we conducted a systematic search in three databases. Our analysis encompassed human studies that measured the periodontal pocket depth, the clinical attachment level, and the depth of the intra-bony defect. Meta-analyses were carried out using random effects model to compare the mean differences between the study group, which received 1% MF gel locally in addition to traditional scaling and root planing (SRP), and the control group, which received a placebo in addition to conventional treatment.

Results: Following the selection procedure, six articles were selected for inclusion in our meta-analysis, out of the 246 articles identified through the systematic search. After three and six months of follow-up, meta-analyses revealed statistically significant differences between the control and study groups. The overall effect for PD was a 1.33 mm reduction (95% confidence interval (CI): -1.66; -1.01) after three months and 1.87 mm (-2.24; -1.39) after six months. The overall effect of CAL was 1.80 mm (-2.26; -1.34) after three months and 2.14 mm (-2.71; -1.58) after six months. The change in IBD after a six-month follow-up was 1.16 mm (-1.40; -0.92).

Conclusion: The application of 1% MF gel enhances the healing process in periodontal diseases, when employed in conjunction with conventional therapy.

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来源期刊
Saudi Dental Journal
Saudi Dental Journal DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.60
自引率
0.00%
发文量
86
审稿时长
22 weeks
期刊介绍: Saudi Dental Journal is an English language, peer-reviewed scholarly publication in the area of dentistry. Saudi Dental Journal publishes original research and reviews on, but not limited to: • dental disease • clinical trials • dental equipment • new and experimental techniques • epidemiology and oral health • restorative dentistry • periodontology • endodontology • prosthodontics • paediatric dentistry • orthodontics and dental education Saudi Dental Journal is the official publication of the Saudi Dental Society and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.
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