Brendan K Tao, Faizan Naveed, Salem A Al-Burak, Kate Lim, Amir R Vosoughi, Kenneth Chang, Christian El-Hadad, Georges Nassrallah, Ahsen Hussain, Bryan Arthurs, Navdeep Nijhawan, Edsel B Ing
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The most common constitutive symptom was PV in 35.6% (95% CI [29.5, 42.3], I<sup>2</sup> = 71.1%, six studies), followed by PP in 26.4% (95% CI [20.8, 32.9], I<sup>2</sup> = 76.1%, seven studies) and PNVNP in 19.9% (95% CI [7.9, 42.0], I<sup>2</sup> = 91.2%, six studies) sensations. The pooled prevalence of reporting all three constitutive symptoms simultaneously was 4.8% (95% CI [2.2, 10.1], I<sup>2</sup> = 67.3%, three studies). Commonly reported risk factors in the literature included mental health comorbidities and preoperative pain, though some studies did not conduct multivariable analysis to control for confounding factors.</p><p><strong>Conclusions: </strong>Low certainty evidence supports that over 50% of patients may develop at least one constitutive PES symptom. Patients may benefit from PES screening, reassurance, and early treatment of postoperative pain.</p>","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1-8"},"PeriodicalIF":0.8000,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prevalence of phantom eye syndrome following eye removal: a systematic review and meta-analysis.\",\"authors\":\"Brendan K Tao, Faizan Naveed, Salem A Al-Burak, Kate Lim, Amir R Vosoughi, Kenneth Chang, Christian El-Hadad, Georges Nassrallah, Ahsen Hussain, Bryan Arthurs, Navdeep Nijhawan, Edsel B Ing\",\"doi\":\"10.1080/01676830.2025.2546549\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To determine the literature-pooled prevalence of phantom eye syndrome (PES) following eye removal, including phantom vision (PV), phantom pain (PP), or phantom non-visual non-painful (PNVNP) sensations.</p><p><strong>Methods: </strong>Databases were searched from inception to March 12 2025. A systematic review and meta-analysis of PES prevalence and risk factors was conducted.</p><p><strong>Results: </strong>Seven studies were identified (775 patients). The literature-pooled prevalence of PES, defined as having at least one constitutive symptom, was 58.9% (95% CI [50.4, 66.9], I<sup>2</sup> = 78%, five studies). The most common constitutive symptom was PV in 35.6% (95% CI [29.5, 42.3], I<sup>2</sup> = 71.1%, six studies), followed by PP in 26.4% (95% CI [20.8, 32.9], I<sup>2</sup> = 76.1%, seven studies) and PNVNP in 19.9% (95% CI [7.9, 42.0], I<sup>2</sup> = 91.2%, six studies) sensations. The pooled prevalence of reporting all three constitutive symptoms simultaneously was 4.8% (95% CI [2.2, 10.1], I<sup>2</sup> = 67.3%, three studies). Commonly reported risk factors in the literature included mental health comorbidities and preoperative pain, though some studies did not conduct multivariable analysis to control for confounding factors.</p><p><strong>Conclusions: </strong>Low certainty evidence supports that over 50% of patients may develop at least one constitutive PES symptom. Patients may benefit from PES screening, reassurance, and early treatment of postoperative pain.</p>\",\"PeriodicalId\":47421,\"journal\":{\"name\":\"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery\",\"volume\":\" \",\"pages\":\"1-8\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/01676830.2025.2546549\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/01676830.2025.2546549","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的：确定眼球摘除后幻眼综合征（PES）的文献汇总患病率，包括幻视（PV）、幻痛（PP）或幻非视觉非疼痛（PNVNP）感觉。方法：检索自建库至2025年3月12日的数据库。对PES患病率和危险因素进行了系统回顾和荟萃分析。结果：共纳入7项研究（775例患者）。PES（定义为至少有一种构成症状）的文献汇总患病率为58.9% （95% CI [50.4, 66.9], I2 = 78%， 5项研究）。最常见的构成症状是PV，占35.6% （95% CI [29.5, 42.3], I2 = 71.1%， 6项研究），其次是PP，占26.4% （95% CI [20.8, 32.9], I2 = 76.1%， 7项研究）和PNVNP，占19.9% （95% CI [7.9, 42.0], I2 = 91.2%， 6项研究）。同时报告所有三种构成症状的总患病率为4.8% （95% CI [2.2, 10.1], I2 = 67.3%， 3项研究）。文献中通常报道的危险因素包括精神健康合并症和术前疼痛，尽管一些研究没有进行多变量分析以控制混杂因素。结论：低确定性证据支持超过50%的患者可能出现至少一种构成性PES症状。患者可以从PES筛查、保证和术后疼痛的早期治疗中获益。
Prevalence of phantom eye syndrome following eye removal: a systematic review and meta-analysis.
Purpose: To determine the literature-pooled prevalence of phantom eye syndrome (PES) following eye removal, including phantom vision (PV), phantom pain (PP), or phantom non-visual non-painful (PNVNP) sensations.
Methods: Databases were searched from inception to March 12 2025. A systematic review and meta-analysis of PES prevalence and risk factors was conducted.
Results: Seven studies were identified (775 patients). The literature-pooled prevalence of PES, defined as having at least one constitutive symptom, was 58.9% (95% CI [50.4, 66.9], I2 = 78%, five studies). The most common constitutive symptom was PV in 35.6% (95% CI [29.5, 42.3], I2 = 71.1%, six studies), followed by PP in 26.4% (95% CI [20.8, 32.9], I2 = 76.1%, seven studies) and PNVNP in 19.9% (95% CI [7.9, 42.0], I2 = 91.2%, six studies) sensations. The pooled prevalence of reporting all three constitutive symptoms simultaneously was 4.8% (95% CI [2.2, 10.1], I2 = 67.3%, three studies). Commonly reported risk factors in the literature included mental health comorbidities and preoperative pain, though some studies did not conduct multivariable analysis to control for confounding factors.
Conclusions: Low certainty evidence supports that over 50% of patients may develop at least one constitutive PES symptom. Patients may benefit from PES screening, reassurance, and early treatment of postoperative pain.
期刊介绍：
Orbit is the international medium covering developments and results from the variety of medical disciplines that overlap and converge in the field of orbital disorders: ophthalmology, otolaryngology, reconstructive and maxillofacial surgery, medicine and endocrinology, radiology, radiotherapy and oncology, neurology, neuroophthalmology and neurosurgery, pathology and immunology, haematology.
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