评价多种抗氧化治疗对不同程度精索静脉曲张不育男性精子参数、生殖激素、精子DNA完整性和妊娠率的影响。

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY
Chaymae Rochdi, Meriem Ouadrhiri, Ibtissam Bellajdel, Hafsa Taheri, Hanane Saadi, Ahmed Mimouni, Mohammed Choukri
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引用次数: 0

摘要

目的:本研究强调氧化应激在男性不育(包括精索静脉曲张)发病机制中的作用,并支持抗氧化剂补充的效用。本研究的目的是评价多种抗氧化治疗在不同程度精索静脉曲张少弱精子症(OA)患者改善精液质量、降低DNA断裂指数和提高妊娠率方面的有效性。方法:我们对患有OA和不同程度精索静脉曲张的不育男性进行了前瞻性研究。在基线和治疗6个月后收集精索静脉曲张0、1、2和3级患者的血清和精液样本。评估精子DNA损伤、生殖激素和妊娠率。结果:G1、G2、G3和G4组患者的平均精子数、总精子数、精子活力和正常精子形态均有显著差异(结论:综合抗氧化治疗对0级和1级精索静脉曲张患者有显著的治疗效果,可作为精索静脉曲张相关性不孕的有效辅助治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Evaluation of the effects of multiantioxidant therapy on sperm parameters, reproductive hormones, sperm DNA integrity, and pregnancy rates in infertile men with different grades of varicocele.

Evaluation of the effects of multiantioxidant therapy on sperm parameters, reproductive hormones, sperm DNA integrity, and pregnancy rates in infertile men with different grades of varicocele.

Objective: This study emphasizes the role of oxidative stress in the pathogenesis of male infertility-including varicocele-and supports the utility of antioxidant supplementation. The aim of our study is to evaluate the effectiveness of multiantioxidant therapy in improving semen quality, reducing the DNA fragmentation index, and increasing pregnancy rates in oligoasthenozoospermic (OA) patients with different grades of varicocele.

Methods: We conducted a prospective study of infertile men with OA and varying grades of varicocele. Serum and semen samples were collected at baseline and after 6 months of treatment from subjects with varicocele grades 0, 1, 2, and 3. Sperm DNA damage, reproductive hormones, and pregnancy rates were evaluated.

Results: Significant differences in mean sperm count, total sperm count, sperm motility, and normal sperm morphology were observed among groups G1, G2, G3, and G4 (p<0.0001). Sperm DNA integrity improved significantly in patients with varicocele after oral antioxidant therapy. Pregnancy achieved by intrauterine insemination was observed in 11%, 9%, 1%, and 0.7% of couples in groups G1, G2, G3, and G4, respectively. Additionally, spontaneous pregnancy occurred in 6% and 3% of couples with varicocele grade 0 and grade 1, respectively, after multiantioxidant supplementation. No significant pregnancy rate was observed in groups G3 and G4.

Conclusion: Multiantioxidant therapy produced marked therapeutic benefits in patients with grade 0 and grade 1 varicocele and served as a useful adjuvant in managing varicocele-related infertility.

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