Stephanie A Meyers-Pantele, Jonathan L Helm, Michael Miller-Perusse, Junye Ma, Keith J Horvath
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Generalized estimating equations (GEEs) models examined longitudinal associations, including between- and within-person effects, between resilience scores and self-reported 30-day ART adherence, dichotomized as optimal (≥ 90% of doses) versus suboptimal (< 90% of doses) across the 17-month study timeframe, while controlling for covariates. Among 401 SMM with HIV that completed the TWM baseline assessment (<i>M</i> <sub>age</sub> = 39.1 years, Standard Deviation = 10.8), 59.9% self-identified as Black/African American. In GEE models, resilience scores were prospectively associated with optimal 30-day ART adherence (<i>b</i> = 0.06, <i>β</i> = 0.38, <i>p</i> < 0.001), at the between-person level, above the effects of covariates. In moderation analyses, resilience scores were associated with optimal ART adherence among Black/African American SMM but not among those identifying as White or another race. 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引用次数: 0
摘要
尽管在性少数男性(SMM)感染艾滋病毒的艾滋病毒抗逆转录病毒治疗(ART)依从性和病毒抑制方面存在种族差异,但恢复力可能是一个重要的保护因素。然而,在这一群体中,缺乏探索恢复力和抗逆转录病毒治疗依从性之间纵向关联的研究。因此,目前的研究检查了不同种族的艾滋病毒感染者的恢复力和抗逆转录病毒治疗依从性之间的前瞻性关联,包括人与人之间和人与人之间的影响。数据来自Thrive With Me (TWM),这是一项针对SMM中ART依从性的移动健康干预的随机对照试验。广义估计方程(GEEs)模型检验了纵向关联,包括人与人之间的影响,恢复力评分和自我报告的30天抗逆转录病毒治疗依从性之间的关系,分为最佳(≥90%的剂量)和次优(M年龄= 39.1岁,标准差= 10.8),59.9%自我认定为黑人/非裔美国人。在GEE模型中,恢复力评分与最佳30天抗逆转录病毒治疗依从性在人间水平上具有前瞻性相关(b = 0.06, β = 0.38, p < 0.001),高于协变量的影响。在适度分析中,弹性得分与黑人/非裔美国人SMM的最佳抗逆转录病毒治疗依从性有关,但与那些被认定为白人或其他种族的人无关。这些结果表明,增强韧性可能是未来干预措施的一个重要策略,旨在随着时间的推移改善种族和民族多样化的艾滋病毒感染者抗逆转录病毒治疗的依从性。
Resilience and ART Adherence Among a Sample of Racially and Ethnically Diverse Sexual Minority Men With HIV.
While racial disparities in HIV antiretroviral treatment (ART) adherence and viral suppression among sexual minority men (SMM) with HIV persist, resilience may serve as an important protective factor. There is, however, a dearth of research exploring the longitudinal associations between resilience and ART adherence among this group. As such, the current study examined prospective associations, including the between- and within-person effects, between resilience and ART adherence among racially diverse SMM with HIV. Data were drawn from Thrive With Me (TWM), a randomized controlled trial of an mHealth intervention targeting ART adherence among SMM. Generalized estimating equations (GEEs) models examined longitudinal associations, including between- and within-person effects, between resilience scores and self-reported 30-day ART adherence, dichotomized as optimal (≥ 90% of doses) versus suboptimal (< 90% of doses) across the 17-month study timeframe, while controlling for covariates. Among 401 SMM with HIV that completed the TWM baseline assessment (Mage = 39.1 years, Standard Deviation = 10.8), 59.9% self-identified as Black/African American. In GEE models, resilience scores were prospectively associated with optimal 30-day ART adherence (b = 0.06, β = 0.38, p < 0.001), at the between-person level, above the effects of covariates. In moderation analyses, resilience scores were associated with optimal ART adherence among Black/African American SMM but not among those identifying as White or another race. These results suggest bolstering resilience may be an important strategy for future interventions aiming to improve ART adherence over time for racially and ethnically diverse SMM with HIV.
期刊介绍:
AIDS Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focused on all aspects of HIV and AIDS, from the molecular basis of disease to translational and clinical research. In addition, articles relating to prevention, education, and behavior change will be considered