[Expression of NOD-like receptors in periodontal tissues of patients with aggressive periodontitis].

Objective: To study the expression of NOD-like receptors (NLRs) in periodontal tissue cells of patients with aggressive periodontitis before and after complex treatment.

Material and methods: An immunohistochemical study of NLR expression (NOD1, NOD2, NLRC3, NLRP3, NLRP7, NLRP12, NAIP) was performed in periodontal tissue samples from patients with aggressive periodontitis before and after complex treatment, as well as in samples of the gingival mucosa of patients with gingival fibroids without signs of inflammation, who served as a control group.

Results: In the control group, NLR expression in the multilayer squamous epithelium of the gingival mucosa was not detected. In patients with aggressive periodontitis, during the exacerbation period, pronounced expression of all studied NLRs was revealed in the inflammatory infiltrate cells of the subepithelial tissues of the periodontal pocket, as well as NOD1, NLRP3, NLRP12 and NAIP in the nuclei and cytoplasm of the cells of the multilayer squamous epithelium of the periodontal pocket. During complex treatment, the expression of most NLRs in epithelial cells persists for 21 days, while it decreases in the inflammatory infiltrate cells of the subepithelial tissues of the periodontal pocket.

Conclusion: Statistically significant differences between IHC expression parameters before and after treatment according to the criterion of "inflammatory infiltrate" were found among such receptors as NAIP, NLRP12 and NLRP7.