Association of the SLC6A3 Gene rs2652511 Polymorphism with Methamphetamine Abuse Disorder in the Iranian Population.

Background: Besides its physical and psychological effects on individuals, addiction is a major personal and societal issue that threatens cultural, political, and community well-being. Genetic factors play essential roles in susceptibility to methamphetamine dependence. The purpose of this study was to investigate the correlation between methamphetamine use disorder in Iranian males and the rs2652511 polymorphism in the promoter of SLC6A3.

Methods: We recruited 100 men with methamphetamine use disorder as cases and 100 age- and ethnically-matched normal men from East Azerbaijan, Tabriz, Iran as healthy controls. From peripheral blood leukocytes, genomic DNA was extracted. PCR-RFLP was utilized for genotyping.

Findings: The genotype distribution of rs2652511 polymorphism in the case group was 56% CC, 33% CT, and 11% 44, whereas in the control group it was 25% CC, 42% CT, and 33% TT. According to statistical analysis, there was a substantial variation in genotype and allele frequencies of the rs2652511 polymorphism between the case group and the healthy control group (P>0.05).

Conclusion: Our research revealed that the rs2652511 polymorphism in the SLC6A3 gene was associated with methamphetamine misuse disorder in the Iranian population. To clarify the exact role of this polymorphism in the pathology of methamphetamine use disorder, further research is required across different racial and geographic groups.